864244-98-4

Basic information

• Product Name: 4-(2-Methyl-4-Nitrophenoxy)Pyridin-2-Amine
• Synonyms: 4-(2-Methyl-4-Nitrophenoxy)Pyridin-2-Amine;4-(2-Methyl-4-Nitrophenoxy)Pyridin-2-Amine(WXC01437)
• CAS NO: 864244-98-4
• Molecular Formula: C₁₂H₁₁N₃O₃
• Molecular Weight: 245.23404
• Mol File: 864244-98-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 408.4±40.0 °C(Predicted)
• Appearance: /
• Density: 1.335±0.06 g/cm3(Predicted)
• PKA: 6.54±0.11(Predicted)
• CAS DataBase Reference: 4-(2-Methyl-4-Nitrophenoxy)Pyridin-2-Amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Methyl-4-Nitrophenoxy)Pyridin-2-Amine(864244-98-4)
• EPA Substance Registry System: 4-(2-Methyl-4-Nitrophenoxy)Pyridin-2-Amine(864244-98-4)

Safety Data

• Hazardous Substances Data: 864244-98-4(Hazardous Substances Data)

Usage

General Description

4-(2-Methyl-4-Nitrophenoxy)Pyridin-2-Amine is a chemical compound with the molecular formula C12H11N3O3. It is a pyridinamine derivative with a nitrophenyl group attached to the pyridine ring. This chemical is commonly used in the synthesis of various pharmaceutical compounds and agrochemicals due to its ability to inhibit certain biological processes. Its structure and properties make it a valuable building block for the development of new drugs and pesticides. Additionally, it has potential applications in the field of materials science, particularly in the development of organic semiconductors and dyes. However, it is important to handle this chemical with care and in accordance with proper safety protocols due to its potential hazards.

Upstream product

• 19798-80-2 2-Amino-4-chloropyridine 
• 99586-65-9 4-chloropicolinamide 
• 98-98-6 2-Picolinic acid 
• 202216-99-7 4-chloro-2-pyridinamine hydrochloride 
• 455-88-9 5-nitro-2-fluorotoluene 
• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 33631-05-9 2-amino-4-hydroxypyridine 
• 99-53-6 2-methyl-4-nitrophenol 
• 65370-42-5 4-chloro-2-nitropyridine 
• 937263-40-6 tert-butyl 4-(2-methyl-4-nitrophenoxy)pyridin-2-ylcarbamate 

Downstream Products

• 937263-41-7 7-(2-methyl-4-nitrophenoxy)imidazo [1,2-a]pyridine 
• 937263-44-0 7-(2-methyl-4-nitrophenoxy)-[1,2,4]triazolo[1,5-a] pyridine 
• 937263-71-3 4-([1,2,4]triazolo[1,5-α]pyridin-7-yloxy)-3-methylaniline 
• 937263-43-9 tucatinib 
• 1229607-60-6 2-methoxy-N-(4-(2-methyl-4-nitrophenoxy)pyridin-2-yl)acetamide 
• 864245-03-4 1-(3-diethylaminopropyl)-3-[4-(2-methyl-4-nitrophenoxy)pyridin-2-yl]urea 

Relevant articles and documents

ALKYNYL QUINAZOLINE COMPOUNDS

The present disclosure relates to compounds of Formula (I'): and pharmaceutically acceptable salts and stereoisomers thereof. The present disclosure also relates to methods of preparation these compounds, compositions comprising these compounds, and methods of using them in the prevention or treatment of abnormal cell growth in mammals, especially humans.

Synthesis method of Tucatinib and intermediate product thereof

The invention discloses a synthesis method of Tucatinib, and the method comprises the following step: carrying out substitution reaction on halate of a compound shown in a formula VI or free alkali thereof serving as a raw material and a compound shown in a formula VII under an alkaline condition to obtain a compound shown in a formula VIII. The raw materials used in the whole synthesis route areeasy to obtain, expensive catalysts are not needed, and the method is suitable for large-scale production and beneficial to industrial production of the Tucatinib.

ERBB RECEPTOR INHIBITORS

Disclosed are compounds inhibiting ErbBs (e. g. HER2), pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compound and the pharmaceutical composition can effectively treat diseases associated ErbBs (especially HER2), including cancer.