86427-02-3

Basic information

• Product Name: 3-Chlorothiophene-2-carbonyl chloride
• Synonyms: TIMTEC-BB SBB005473;3-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE;BUTTPARK 29\06-44;2-Thiophenecarbonyl chloride, 3-chloro- (9CI);3-Chlorothiophene-2-carbonyl chloride 98%;3-Chlorothiophene-2-carbonylchloride98%;3-Chlorothiophene-2-carbonyl chloride ,97%;3-Chloro-2-(chlorocarbonyl)thiophene
• CAS NO: 86427-02-3
• Molecular Formula: C₅H₂Cl₂OS
• Molecular Weight: 181.04
• Product Categories: ACIDHALIDE;Thiophene&Benzothiophene
• Mol File: 86427-02-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 43-44
• Boiling Point: 113°C 0,5mm
• Flash Point: 98.5 °C
• Appearance: white to light yellow crystal powder
• Density: 1.543 g/cm³
• Vapor Pressure: 0.0405mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 3-Chlorothiophene-2-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chlorothiophene-2-carbonyl chloride(86427-02-3)
• EPA Substance Registry System: 3-Chlorothiophene-2-carbonyl chloride(86427-02-3)

Safety Data

• Hazard Codes: Xi,C
• Statements: 34-36
• Safety Statements: 26-36/37/39-45
• RIDADR: 3261
• Hazardous Substances Data: 86427-02-3(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

Uses

3-Chloro-2-thiophenecarbonyl Chloride is one of the reactants in synthesis of 5-?(3-?chlorothiophen-?2-?yl)?-?3-?(4-?trifluoromethylphenyl)?-?1,?2,?4-?oxadiazole, a novel apoptosis inducer.

InChI:InChI=1/C5H2Cl2OS/c6-3-1-2-9-4(3)5(7)8/h1-2H

Downstream Products

• 721450-85-7 5-(3-chlorothiophen-2-yl)-3-(4-chloro-3-(N-methyl-N-(4-butyric acid methyl ester)-amino)-phenyl)-[1,2,4]-oxadiazole 
• 147123-67-9 3-chlorothiophene-2-carbonitrile 
• 478488-89-0 3-(4-Butoxy-phenyl)-5-(3-chloro-thiophen-2-yl)-[1,2,4]-oxadiazole 
• 478489-00-8 3-(4-Acetamido-phenyl)-5-(3-chloro-thiophen-2-yl)-[1,2,4]-oxadiazole 
• 478489-03-1 3-(2-Amino-4-chloro-phenyl)-5-(3-chloro-thiophen-2-yl)-[1,2,4]-oxadiazole 
• 478489-09-7 5-(3-Chloro-thiophen-2-yl)-3-(4-cyano-phenyl)-[1,2,4]-oxadiazole 
• 478489-13-3 5-(3-Chloro-thiophen-2-yl)-3-[4-(methyl carboxy)-phenyl]-[1,2,4]-oxadiazole 
• 478489-24-6 5-(3-Chloro-thiophen-2-yl)-3-[2-(4-chloro-phenyl)-ethyl]-[1,2,4]-oxadiazole 
• 478489-25-7 5-(3-Chloro-thiophen-2-yl)-3-(4-chloro-phenoxymethyl)-[1,2,4]-oxadiazole 
• 366789-02-8 Rivaroxaban 
• 1255908-04-3 benzyl N,N'-di(3-chlorothien-2-ylcarbonyl)-imidoselenocarbamate 
• 1385073-50-6 C₂₆H₂₈ClN₃O₇S 
• 59337-89-2 3-chlorothiophene-2-carboxylic acid 

Relevant articles and documents

Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, Ar3, A, B and D are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.