147123-67-9

Usage

Uses

Used in Organic Chemistry Research and Development:
3-Chloro-2-Cyanothiophene is employed as a key compound in the field of organic chemistry, particularly for the synthesis of various organic molecules and materials. Its unique structure and reactivity make it a valuable intermediate in the development of new chemical entities and processes.
Used in Chemical Synthesis:
3-Chloro-2-Cyanothiophene is used as a building block in the synthesis of complex organic molecules, contributing to the advancement of pharmaceuticals, agrochemicals, and other specialty chemicals. Its reactivity with oxidizing agents, acids, and bases allows for a wide range of chemical transformations, facilitating the creation of diverse molecular structures.
Used in Material Science:
3-Chloro-2-Cyanothiophene is utilized in the development of novel materials with specific properties, such as electronic, optical, or mechanical characteristics. Its incorporation into polymers, coatings, or other composites can lead to the creation of innovative materials with enhanced performance in various applications.

Upstream product

• 147123-68-0 3-chloro-thiophene-2-carboxamide 
• 420-04-2 CYANAMID 
• 86427-02-3 3-chlorothiophene-2-carbonyl chloride 
• 137844-98-5 3-aminothiophene-2-carbohydrazide 
• 147123-50-0 thieno<3,2-d>-1,2,3-triazin-4(3H)-one 
• 544-92-3 copper(I) cyanide 
• 77893-68-6 2-bromo-3-chlorothiophene 

Downstream Products

• 32431-84-8 3-fluoro-2-thiophenecarboxylic acid 
• 154499-46-4 2-cyano-3-fluorothiophene 

Relevant academic research and scientific papers

Mechanistic Insight Facilitates Discovery of a Mild and Efficient Copper-Catalyzed Dehydration of Primary Amides to Nitriles Using Hydrosilanes

Metal-catalyzed silylative dehydration of primary amides is an economical approach to the synthesis of nitriles. We report a copper-hydride(CuH)-catalyzed process that avoids a typically challenging 1,2-siloxane elimination step, thereby dramatically increasing the rate of the overall transformation relative to alternative metal-catalyzed systems. This new reaction proceeds at ambient temperature, tolerates a variety of metal-, acid-, or base-sensitive functional groups, and can be performed using a simple ligand, inexpensive siloxanes, and low catalyst loading.

Thrombin inhibitors

Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, and use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory agents.

Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, Ar3, A, B and D are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

A convenient synthesis of 3-fluorothiophene

2-bromo-3-chlorothiophene 2 underwent nucleophilic aromatic substitution using cyanocupper to give 2-cyano-3-chlorothiophene 3 which, after fluoration with CsF, hydrolysis and decarboxylation gave 3-fluorothiophene 6 in good yield. The electropolymerisation of 6 is also described.