864277-00-9Relevant academic research and scientific papers
Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors
Anandan, Sampath-Kumar,Ward, John S.,Brokx, Richard D.,Denny, Trisha,Bray, Mark R.,Patel, Dinesh V.,Xiao, Xiao-Yi
, p. 5995 - 5999 (2007)
We have designed and synthesized a series of structurally novel hydroxamic acid-based histone deacetylase (HDAC) inhibitors characterized by a zinc chelating head group attached directly to a thiazole ring. The thiazole ring connects to a piperazine spacer, which is capped with a sulfonamide group. These novel molecules potently inhibit an HDAC enzyme mixture derived from HeLa cervical carcinoma cells and show potent antiproliferative activity against the breast cancer cell line MCF7.
Inhibitors of histone deacetylase
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Page/Page column 38, (2008/06/13)
Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly proliferative conditions, mediated at least
