864378-36-9Relevant academic research and scientific papers
Benzofuro[3,2-b]pyridines as mixed ET(A)/ET(B) and selective ET(B) endothelin receptor antagonists
Mederski, Werner W. K. R.,Osswald, Mathias,Dorsch, Dieter,Christadler, Maria,Schmitges, Claus-Jochen,Wilm, Claudia
, p. 619 - 622 (1999)
The discovery, synthesis and structure-activity relationships of a series of novel benzofuro[3,2b]pyridines as non-selective endothelin ET(A)/ET(B) as well as selective ET(B) receptor antagonists are described. The most potent non-selective inhibitor 7s d
Synthesis and biological evaluation of 2-(3′,4′,5′-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization
Romagnoli, Romeo,Baraldi, Pier Giovanni,Sarkar, Taradas,Carrion, Maria Dora,Cruz-Lopez, Olga,Lopez Cara, Carlota,Tolomeo, Manlio,Grimaudo, Stefania,Di Cristina, Antonietta,Pipitone, Maria Rosaria,Balzarini, Jan,Gambari, Roberto,Ilaria, Lampronti,Saletti, Roberto,Brancale, Andrea,Hamel, Ernest
experimental part, p. 8419 - 8426 (2009/04/11)
Molecules that target microtubules have an important role in the treatment of cancer. A new class of inhibitors of tubulin polymerization based on the 2-(3,4,5-trimethoxybenzoyl)-2-dimethylamino-benzo[b]furan molecular skeleton was synthesized and evaluat
Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles
Romagnoli, Romeo,Baraldi, Pier Giovanni,Jung, M. Katherine,Iaconinoto, Maria Antonietta,Carrion, Maria Dora,Remusat, Vincent,Preti, Delia,Tabrizi, Mojgan Aghazadeh,Francesca, Fruttarolo,De Clercq, Erik,Balzarini, Jan,Hamel, Ernest
, p. 4048 - 4052 (2007/10/03)
A new series of compounds, in which the 2-amino-4-methoxyphenyl ring of phenstatin analogue 5 was replaced with 2- or 3-amino-benzoheterocycles, was synthesized and evaluated for antiproliferative activity and inhibition of colchicine binding. The lack of
