Benzofuro[3,2-b]pyridines as mixed ET(A)/ET(B) and selective ET(B) endothelin receptor antagonists

Article abstract of DOI:10.1016/S0960-894X(99)00040-2

The discovery, synthesis and structure-activity relationships of a series of novel benzofuro[3,2b]pyridines as non-selective endothelin ET(A)/ET(B) as well as selective ET(B) receptor antagonists are described. The most potent non-selective inhibitor 7s d