864514-16-9

Upstream product

• 861842-45-7 (+)-(2S,3S)-2-hydroxy-3-methoxy-5-methylhex-5-enoic acid 
• 98-88-4 benzoyl chloride 
• 861842-51-5 (4S,5R)-5,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-2-methyl-hex-1-ene 
• 864514-19-2 Benzoic acid (1R,2S)-1-hydroxymethyl-2-methoxy-4-methyl-pent-4-enyl ester 
• 864514-36-3 (2R,3S)-1-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-5-methyl-hex-5-en-2-ol 
• 861842-42-4 (R)-4-((S)-1-Methoxy-3-methyl-but-3-enyl)-2,2-dimethyl-[1,3]dioxolane 
• 861842-50-4 (2R,3S)-3-methoxy-5-methyl-5-hexene-1,2-diol 

Downstream Products

• 957770-49-9 C₁₅H₁₉NO₄ 
• 1336892-06-8 C₆₆H₁₁₉NO₁₃Si₅ 
• 864514-33-0 Benzoic acid (1S,2S)-1-chlorocarbonyl-2-methoxy-4-methyl-pent-4-enyl ester 

Relevant academic research and scientific papers

Total Synthesis of Psymberin (Irciniastatin A)

A convergent, stereocontrolled total synthesis of psymberin, an architecturally complex marine antitumor agent, has been achieved in 27 steps from the known aldehyde 8. Highlights of this synthesis include a novel and efficient transannular Michael additi

Preparation method of Psymberin

The invention belongs to the field of chemical synthesis, and more specifically relates to a preparation method of Psymberin. The preparation method comprises following steps: a compound 2 is subjected to derivatization so as to obtain an acyl chloride co

Studies toward the unique pederin family member psymberin: Full structure elucidation, two alternative total syntheses, and analogs

Two synthetic approaches to psymberin have been accomplished. A highly convergent first generation synthesis led to the complete stereochemical assignment and demonstrated that psymberin and irciniastatin A are identical compounds. This synthesis featured

Synthesis and complete stereochemical assignment of psymberin/irciniastatin for use as antitumor compounds

The invention relates to the synthesis and complete stereochemical assignments of cytotoxic compounds such as compound 28-a and its stereoisomers: The invention further provides processes for making the compounds, their synthetic intermediates, and for me

Direct carbinolamide synthesis

Carbinolamides were prepared by treatment of aldehydes with carboxamides in the presence of dicyclohexylboron chloride and triethylamine. All carbinolamide products were stable to isolation, purification and routine handling.

Synthesis and complete stereochemical assignment of psymberin/irciniastatin A

We describe a concise and flexible synthetic avenue for the preparation of compounds with structures relevant to those proposed for the novel marine-derived differential cytotoxins psymberin and irciniastatin A. Our efforts led to their complete stereoche