864514-19-2Relevant academic research and scientific papers
Preparation method of Psymberin
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Paragraph 0048-0051, (2019/07/16)
The invention belongs to the field of chemical synthesis, and more specifically relates to a preparation method of Psymberin. The preparation method comprises following steps: a compound 2 is subjected to derivatization so as to obtain an acyl chloride co
Total Synthesis of Psymberin (Irciniastatin A)
Yu, Jie,Yang, Mingze,Guo, Yian,Ye, Tao
, p. 3670 - 3673 (2019/05/24)
A convergent, stereocontrolled total synthesis of psymberin, an architecturally complex marine antitumor agent, has been achieved in 27 steps from the known aldehyde 8. Highlights of this synthesis include a novel and efficient transannular Michael additi
Studies toward the unique pederin family member psymberin: Full structure elucidation, two alternative total syntheses, and analogs
Feng, Yu,Jiang, Xin,De Brabander, Jef K.
, p. 17083 - 17093 (2013/01/15)
Two synthetic approaches to psymberin have been accomplished. A highly convergent first generation synthesis led to the complete stereochemical assignment and demonstrated that psymberin and irciniastatin A are identical compounds. This synthesis featured
Synthesis and complete stereochemical assignment of psymberin/irciniastatin for use as antitumor compounds
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Page/Page column 11, (2010/11/25)
The invention relates to the synthesis and complete stereochemical assignments of cytotoxic compounds such as compound 28-a and its stereoisomers: The invention further provides processes for making the compounds, their synthetic intermediates, and for me
Synthesis and complete stereochemical assignment of psymberin/irciniastatin A
Jiang, Xin,Garcia-Fortanet, Jorge,De Brabander, Jef K.
, p. 11254 - 11255 (2007/10/03)
We describe a concise and flexible synthetic avenue for the preparation of compounds with structures relevant to those proposed for the novel marine-derived differential cytotoxins psymberin and irciniastatin A. Our efforts led to their complete stereoche
