86454-13-9

Basic information

• Product Name: 2-HYDROXY-6-METHYLISONICOTINIC ACID
• Synonyms: 2-HYDROXY-6-METHYLPYRIDINE-4-CARBOXYLIC ACID;2-HYDROXY-6-METHYLISONICOTINIC ACID;2-HYDROXY-6-METHYLPYRIDINE-4-CARBOXYLIC&;4-Pyridinecarboxylicacid,1,2-dihydro-6-methyl-2-oxo-(9CI);6-Methyl-2-oxo-1,2-dihydro-4-pyridinecarboxylic acid;NSC 124849;2-Hydroxy-6-methylpyridine-4-carboxylic acid, 4-Carboxy-2-hydroxy-6-methylpyridine;2-Hydroxy-6-methylpyridine-4-carboxylic acid 97%
• CAS NO: 86454-13-9
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.14
• EINECS: 626-175-9
• Product Categories: CARBOXYLICACID;Building Blocks;C7 to C8;Chemical Synthesis;Heterocyclic Building Blocks;Pyridines;alcohol| carboxylic acid
• Mol File: 86454-13-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: >300 °C(lit.)
• Boiling Point: 371.2 °C at 760 mmHg
• Flash Point: 178.3 °C
• Appearance: /
• Density: 1.345
• Vapor Pressure: 1.57E-06mmHg at 25°C
• Refractive Index: 1.555
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-HYDROXY-6-METHYLISONICOTINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-6-METHYLISONICOTINIC ACID(86454-13-9)
• EPA Substance Registry System: 2-HYDROXY-6-METHYLISONICOTINIC ACID(86454-13-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 86454-13-9(Hazardous Substances Data)

Usage

General Description

2-HYDROXY-6-METHYLISONICOTINIC ACID is a chemical compound commonly referred to as 2-HMNA, and it is a derivative of isonicotinic acid. It exhibits strong antioxidant and anti-inflammatory properties, and it has been studied for its potential use in the treatment of various diseases and conditions, including cardiovascular disease, diabetes, and neurodegenerative disorders. Additionally, 2-HMNA has shown promise as a therapeutic agent for its ability to prevent oxidative stress and protect cells from damage caused by free radicals. Its unique chemical structure and biological activities make it a promising candidate for further research and development in the field of pharmaceuticals and medicine.

InChI:InChI=1/C7H7NO3/c1-4-2-5(7(10)11)3-6(9)8-4/h2-3H,1H3,(H,8,9)(H,10,11)

Upstream product

• 98436-89-6 3-cyano-2-hydroxy-6-methyl-isonicotinic acid 
• 18619-97-1 ethyl 3-cyano-2-hydroxy-6-methylisonicotinate 
• 615-79-2 ethyl 2,4-diketopentanoate 
• 18619-97-1 3-cyano-6-methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid ethyl ester 
• 86454-12-8 4-methyl-1H-pyrrolo<3,4-c>pyridine-1,3,6(2H,5H)-trione 
• 20577-61-1 methyl 2,4-dioxopentanoate 
• 18724-73-7 methyl 3-cyano-2-hydroxy-6-methyl-isonicotinate 

Downstream Products

• 98491-78-2 methyl 6-methyl-2-hydroxypyridine-4-carboxylate 
• 3998-90-1 2-chloro-6-methyl-isonicotinic acid methyl ester 
• 26413-58-1 2-chloro-6-methyl-4-pyridinecarbonyl chloride 
• 117330-40-2 dimethyl 6,6'-dimethyl-2,2'-bipyridine-4,4'-dicarboxylate 
• 25462-85-5 2-chloro-6-methylpyridine-4-carboxylic acid 
• 150190-03-7 2-hydroxy-6-methylisonicotinic acid ethyl ester 
• 122472-76-8 4-hydroxy-5-methoxy-isophthalaldehyde-bis-(2-methyl-isonicotinoylhydrazone) 
• 101281-47-4 2-methyl-isonicotinic acid-(4-acetylamino-benzylidenehydrazide) 
• 107455-74-3 2-methyl-isonicotinic acid-(4-nitro-benzylidenehydrazide) 
• 101091-68-3 2-methyl-isonicotinic acid vanillylidenehydrazide 
• 101091-50-3 2-methyl-isonicotinic acid-[1-(4-hydroxy-phenyl)-ethylLiDenehydrazide] 
• 101289-92-3 2-methyl-isonicotinic acid-(4-dimethylamino-benzylidenehydrazide) 
• 109017-29-0 2-methyl-isonicotinic acid-(1-[2]furyl-ethylLiDenehydrazide) 
• 101091-51-4 2-methyl-isonicotinic acid-(4-methoxy-benzylidenehydrazide) 

Relevant articles and documents

Synthesis and physico-chemical properties of homoleptic copper(I) complexes with asymmetric ligands as a dssc dye

To develop low-cost and efficient dye-sensitized solar cells (DSSCs), we designed and prepared three homoleptic Cu(I) complexes with asymmetric ligands, M1, M2, and Y3, which have the advantages of heteroleptic-type complexes and compensate for their synthetic challenges. The three copper(I) complexes were characterized by elemental analysis, UV-vis absorption spectroscopy, and electrochemical measurements. Their absorption spectra and orbital energies were evaluated and are discussed in the context of TD-DFT calculations. The complexes have high VOC values (0.48, 0.60, and 0.66 V for M1, M2, and Y3, respectively) which are similar to previously reported copper(I) dyes with symmetric ligands, although their energy conversion efficiencies are relatively low (0.17, 0.64, and 2.66%, respectively).

AROMATIC COMPOUNDS AND METAL COMPLEXES THEREOF

Provided are aromatic compounds and metal complexes thereof which may be useful treating various forms of proliferative diseases, such as cancer. In some instances, the metal complexes thereof are relatively stable, and may be suitable for oral administra

6,6′-Dimethyl-2,2′-bipyridine-4-ester: A pivotal synthon for building tethered bipyridine ligands

We describe an efficient and scalable synthesis of 4-carbomethoxy-6,6′-dimethyl-2,2′-bipyridine starting from easily available substituted 2-halopyridines and based on the application of modified Negishi cross-coupling conditions. This compound is a versatile starting material for the synthesis of 4-functionalized 2,2′-bipyridines bearing halide, alcohol, amine, and other functionalities, suitable for conjugation to biological material (2a-c, 3a-g). The utility of this compound in the construction of more complex architectures was further demonstrated by the synthesis of two bifunctional lanthanide chelators; an open chain ligand based on one 2,2′-bipyridine unit and a cryptand based on three 2,2′-bipyridine units [N2(bpy)3COOMe]. In the field of luminophoric biolabels, the photophysical properties of the corresponding Eu(III) cryptate are reported.