98491-78-2

Basic information

• Product Name: methyl 2-hydroxy-6-methylpyridine-4-carboxylate
• Synonyms: methyl 2-hydroxy-6-methylpyridine-4-carboxylate;1,2-Dihydro-6-methyl-2-oxo-4-pyridinecarboxylic acid methyl ester;1,2-Dihydro-6-methyl-2-oxoisonicotinic acid methyl ester;Methyl 2-hydroxy-6-methylisonicotinate;Methyl 2-hydroxy-6-methylisonicotinate 95+%;METHYL6-METHYL-2-HYDROXYPYRIDINE-4-CARBOXYLATE;Methyl 2-hydroxy-6-methylpyridine-4-carboxylate, 2-Hydroxy-4-(methoxycarbonyl)-6-methylpyridine;4-Pyridinecarboxylic acid, 1,2-dihydro-6-methyl-2-oxo-, methyl ester
• CAS NO: 98491-78-2
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16196
• Mol File: 98491-78-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 224-225℃
• Boiling Point: 365.511°C at 760 mmHg
• Flash Point: 174.855°C
• Appearance: /
• Density: 1.201
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: methyl 2-hydroxy-6-methylpyridine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-hydroxy-6-methylpyridine-4-carboxylate(98491-78-2)
• EPA Substance Registry System: methyl 2-hydroxy-6-methylpyridine-4-carboxylate(98491-78-2)

Safety Data

• Hazardous Substances Data: 98491-78-2(Hazardous Substances Data)

Usage

General Description

Methyl 2-hydroxy-6-methylpyridine-4-carboxylate is a chemical compound with the molecular formula C8H9NO3. It is a derivative of pyridine, containing a methyl group and a carboxylate group. methyl 2-hydroxy-6-methylpyridine-4-carboxylate is typically used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It may also have potential applications in the field of medicinal chemistry and drug development. Methyl 2-hydroxy-6-methylpyridine-4-carboxylate is a versatile building block with various synthetic uses in the production of diverse chemical products.

InChI:InChI=1/C8H9NO3/c1-5-3-6(8(11)12-2)4-7(10)9-5/h3-4H,1-2H3,(H,9,10)

Upstream product

• 186581-53-3 diazomethane 
• 86454-13-9 2-hydroxy-6-methylpyridine-4-carboxylic acid 
• 67-56-1 methanol 
• 956386-40-6 1,6-Dimethyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid 
• 615-79-2 ethyl 2,4-diketopentanoate 
• 18619-97-1 ethyl 3-cyano-2-hydroxy-6-methylisonicotinate 
• 98436-89-6 3-cyano-2-hydroxy-6-methyl-isonicotinic acid 

Downstream Products

• 562086-28-6 methyl 2-methyl-6-<(p-toluenesulfonyl)oxy>pyridine-4-carboxylate 
• 100867-74-1 2-hydroxy-6-methyl-isonicotinic acid benzylidenehydrazide 
• 16830-24-3 methyl 2-methylisonicotinate 
• 25462-85-5 2-chloro-6-methylpyridine-4-carboxylic acid 
• 117330-41-3 4,4'-dimethyl 6,6'-bis(bromomethyl)-[2,2'-bipyridine]-4,4'-dicarboxylate 
• 117330-40-2 dimethyl 6,6'-dimethyl-2,2'-bipyridine-4,4'-dicarboxylate 
• 4411-80-7 6,6'-dimethyl-2,2'-bipyridine 
• 3998-90-1 2-chloro-6-methyl-isonicotinic acid methyl ester 

Relevant articles and documents

Spiro derivative, preparation method thereof and application of spiro derivative in medicine

The invention relates to a spiro derivative, a preparation method thereof and application of the spiro derivative in medicine. Specifically, the invention relates to the spiro derivative shown in a general formula (I), the preparation method thereof, a pharmaceutical composition containing the spiro derivative and application of the spiro derivative as a therapeutic agent, especially application of the spiro derivative as an RAF inhibitor and application of the spiro derivative in preparation of drugs for treating or preventing various diseases (including cancers) related to over-expression RAF activity.