864642-89-7Relevant academic research and scientific papers
A new class of bradykinin B1 receptor antagonists with high oral bioavailability and minimal PXR activity
Feng, Dong-Mei,DiPardo, Robert M.,Wai, Jenny M.,Chang, Ronald K.,Di Marco, Christina N.,Murphy, Kathy L.,Ransom, Richard W.,Reiss, Duane R.,Tang, Cuyue,Prueksaritanont, Thomayant,Pettibone, Douglas J.,Bock, Mark G.,Kuduk, Scott D.
, p. 682 - 687 (2008/09/19)
The design and synthesis of a novel class of human bradykinin B1 antagonists featuring difluoroethyl ether and isoxazole carboxamide moieties are disclosed. Compound 7g displayed excellent pharmacokinetic properties, efficient ex vivo receptor occupancy, and low potential for P450 induction via PXR activation.
AMINO CYCLOPROPANE CARBOXAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS
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Page/Page column 22-23, (2008/06/13)
Compounds disclosed herein are bradykinin Bl antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.
