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864668-60-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 864668-60-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,4,6,6 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 864668-60:
220 % 10 = 0
So 864668-60-0 is a valid CAS Registry Number.

864668-60-0Downstream Products

864668-60-0Relevant articles and documents

Synthesis of neolignans as microtubule stabilisers

Sathish Kumar,Singh, Aastha,Kumar, Amit,Singh, Jyotsna,Hasanain, Mohammad,Singh, Arjun,Masood, Nusrat,Yadav, Dharmendra K.,Konwar, Rituraj,Mitra, Kalyan,Sarkar, Jayanta,Luqman, Suaib,Pal, Anirban,Khan, Feroz,Chanda, Debabrata,Negi, Arvind S.

, p. 1342 - 1354 (2014)

Tubulin is a well established target for anticancer drug development. Lignans and neolignans were synthesized as tubulin interacting agents. Neolignans 10 and 19 exhibited significant anticancer activity against MCF-7 and MDAMB-231 human breast cancer cell lines. Both the compounds effectively induced stabilization of microtubule at 4 and 20 μM concentrations respectively. Neolignan 10 induced G2/M phase arrest in MCF-7 cells. Docking experiments raveled that 10 and 19 occupied the same binding pocket of paclitaxel with some difference in active site amino acids and good bioavailability of both the compounds. In in vivo acute oral toxicity 10 was well tolerated up to 300 mg/kg dose in Swiss-albino mice.

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