864722-39-4Relevant academic research and scientific papers
Stereoselective cyclization reactions of IBX-generated alkoxyamidyl radicals
Janza, Birgit,Studer, Armido
, p. 6991 - 6994 (2007/10/03)
In this paper, a method for the generation of alkoxyamidyl radicals is presented. These N-centered radicals can efficiently be formed starting from the corresponding acylated alkoxyamines using IBX as an oxidant. Stereoselective 5-exo and 6-exo reactions with these N-heteroatom-centered radicals leading to isoxazolidines and [1,2]oxazinanes are discussed. The N-O bond in the heterocycles can readily be cleaved with SmI2 to provide N-acylated 1,3-amino alcohols.
