86475-08-3

Basic information

• Product Name: 2<(4-amino-5-pyrimidinyl)amine>-4-oxo-3-(hydroxymethyl)-4-phenyl-2-butenoic acid
• CAS NO: 86475-08-3
• Molecular Weight: 314.301
• Mol File: 86475-08-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2<(4-amino-5-pyrimidinyl)amine>-4-oxo-3-(hydroxymethyl)-4-phenyl-2-butenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2<(4-amino-5-pyrimidinyl)amine>-4-oxo-3-(hydroxymethyl)-4-phenyl-2-butenoic acid(86475-08-3)
• EPA Substance Registry System: 2<(4-amino-5-pyrimidinyl)amine>-4-oxo-3-(hydroxymethyl)-4-phenyl-2-butenoic acid(86475-08-3)

Safety Data

• Hazardous Substances Data: 86475-08-3(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 88330-79-4 2-hydroxy-4-oxo-4-phenylbut-2-enoic acid ethyl ester 
• 13754-19-3 4,5-pyrimidinediamine 
• 7478-57-1 4-benzoyl-3-hydroxy-2,5-dihydrofuran-2-one 

Relevant articles and documents

Substituted γ-Lactones. XXX (1). Reactions of α-Keto-β-Substituted-γ-butyrolactones with Diamines

The condensation reaction between α-keto-β-aroyl (or acyl)-γ-butyrolactones, 4a-4e and o-phenylenediamine or 2,3-diaminonaphthalene leads under retrograde aldol condensation involving loss of formaldehyde to formation of 3-substituted-3,4-dihydro-2(1H)quinoxalinones or benzoquinoxalinones, 7a-7g, respectively as a new convenient synthesis of this type of heterocyclic systems.The reaction of type 4 compound with 4,5-diaminopyrimidine, 8, was found to proceed differently. 2--4-oxo-3-(hydroxymethyl)-4-phenyl-2-butenoic acid 9 was the only product formed when the reaction between 4a and 8 was run in ethanol.The same reaction in glacial acetic acid proceeds with loss of formaldehyde, to afford 7-phenacylidene-7,8-dihydro-6(1H)-pteridinone 10.The reaction between type 4 compounds and ethylenediamine or 1,4-phenylenediamine leads to the formation of the bis-condensation products 13-15, respectively.