86475-21-0

Upstream product

• 65884-12-0 2,3,4,5-tetramethoxybenzaldehyde 
• 13909-73-4 2',3',4'-trimethoxyacetophenone 
• 19676-64-3 2,3,4-trimethoxyphenol 
• 2103-57-3 2,3,4-trimethoxybenzaldehyde 
• 30225-80-0 2,3,4-trimethoxyphenyl acetate 
• 30225-82-2 2,3,4-trimethoxyphenyl formate 
• 21450-56-6 1,2,3,4-tetramethoxybenzene 

Downstream Products

• 3162-28-5 2-hydroxy-3,4,5,6-tetramethoxyacetophenone 
• 654083-34-8 1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1,3-propanedione 
• 478-01-3 nobiletin 
• 2174-59-6 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone 
• 86475-25-4 β-methoxy-α-(2,3,4,5,6-pentamethoxybenzylidene)propionitrile 
• 86475-27-6 2,4-diamino-5-(2,3,4,5,6-pentamethoxybenzyl)pyrimidine 
• 13909-75-6 1,2,3,4,5-pentamethoxybenzene 
• 30225-99-1 2,3,4,5-Tetramethoxyphenol 

Relevant academic research and scientific papers

Practical Synthesis of Polymethylated Flavones: Nobiletin and Its Desmethyl Derivatives

We present a practical synthesis of the polymethoxylated citrus flavone nobiletin that is suitable for use on a hundred gram scale. Ready availability of this compound and its derivatives will aid detailed chemical-biological investigations of their biological activities, including activation of signaling via the cAMP-dependent protein kinase A/extracellular signal-related protein kinase/cAMP response element-binding protein pathway.

PET imaging of nobiletin based on a practical total synthesis

A practical synthesis of nobiletin, a polymethoxylated citrus flavone, was accomplished by utilizing our novel flavone synthesis. Synthetic nobiletin was labelled by selective demethylation and rapid incorporation of 11C atom. Positron emission tomography images successfully visualized the brain distribution, which may provide therapeutic benefits in the treatment of Alzheimer's disease. The Royal Society of Chemistry.

The Baeyer-Villiger Oxidation of Aromatic Aldehydes and Ketones with Hydrogen Peroxide Catalyzed by Selenium Compounds

A series of organoselenium compounds was investigated as activators of hydrogen peroxide in the Baeyer-Villiger oxidation.As a result, a convenient and cheap method for transformation of aromatic aldehydes, having polycondensed ring systems or electron-donating substituents, and polymethoxy derivatives of acetophenone, into phenols was elaborated.This method utilizes hydrogen peroxide activated by areneseleninic acids, as oxidizing agent.