86477-09-0

Basic information

• Product Name: 4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt
• Synonyms: 4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt;4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt (1:1);5,6-dihydro-4H-Pyrrolo[1,2-b]pyrazole-2-carboxylic acid ethyl ester;Ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate
• CAS NO: 86477-09-0
• Molecular Formula: C₉H₁₂N₂O₂
• Molecular Weight: 190.24098
• EINECS: -0
• Mol File: 86477-09-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 61-63 °C
• Boiling Point: 320.0±30.0 °C(Predicted)
• Appearance: /
• Density: 1.29±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.56±0.20(Predicted)
• CAS DataBase Reference: 4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt(86477-09-0)
• EPA Substance Registry System: 4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt(86477-09-0)

Safety Data

• Hazardous Substances Data: 86477-09-0(Hazardous Substances Data)

Usage

General Description

4H-Pyrrolo [1,2-B] pyrazole-2-carboxylic acid, 5,6-dihydro-, Potassium Salt is a chemical compound that is often used in research and laboratory settings. It is a potassium salt of the carboxylic acid derivative of 4H-Pyrrolo [1,2-B] pyrazole-2. 4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt plays a role in the development of pharmaceuticals and can also be used as a building block in organic synthesis. It is important to handle this chemical with care, as it may pose potential health hazards if not handled properly.

Upstream product

• 98262-66-9 3a,4,5,6-tetrahydro-3-oxo-3H-pyrrolo[1,2-c][1,2,3]oxadiazol-7-ium ylide 
• 623-47-2 propynoic acid ethyl ester 
• 86477-05-6 C₅H₆N₂O₂ 

Downstream Products

• 623564-45-4 (5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-2-yl)methanol 
• 796729-03-8 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid 

Relevant articles and documents

Selective hydrolysis of ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2- carboxylate and ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylate as a key step in the large-scale synthesis of bicyclic heteroaryl carboxyaldehydes

The isomeric mixture of ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]-pyrazole-2- and -3-carboxylates (14 and 15), derived from a proline meso-ionic synthon, demonstrated remarkably different stabilities towards alkaline hydrolysis. On that basis, a non-chromatographic, highly efficient method for their large-scale separation was developed. The desired isomer 14 was converted into 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carbaldehyde, a key intermediate in the synthesis of bicyclic heteroaryl-substituted 6-alkylidene penems.

A serendipitous finding of L-proline as a precursor to novel mesoionic synthon: Delineation of new transformations

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