864818-23-5Relevant articles and documents
Bidirectional, organocatalytic synthesis of lepidopteran sex pheromones
De Figueiredo, Renata Marcia,Berner, Raphael,Julis, Jennifer,Liu, Ting,Tuerp, David,Christmann, Mathias
, p. 640 - 642 (2007)
Shuffling of two simple building blocks and a regioselective transfer hydrogenation allow for the rapid synthesis of a small collection of lepidopteran sex pheromones, e.g., 8E,10Z-tetradeca-8,10-dienal 5c, from the horse chestnut leafminer (Cameraria ohridella).
Stereochemical assignment of the protein-protein interaction inhibitor JBIR-22 by total synthesis
Healy, Alan R.,Izumikawa, Miho,Slawin, Alexandra M. Z.,Shin-Ya, Kazuo,Westwood, Nicholas J.
, p. 4046 - 4050 (2015)
Recent reports have highlighted the biological activity associated with a subfamily of the tetramic acid class of natural products. Despite the fact that members of this subfamily act as protein-protein interaction inhibitors that are of relevance to proteasome assembly, no synthetic work has been reported. This may be due to the fact that this subfamily contains an unnatural 4,4-disubstitued glutamic acid, the synthesis of which provides a key challenge. A highly stereoselective route to a masked form of this unnatural amino acid now enabled the synthesis of two of the possible diastereomers of JBIR-22 and allowed the assignment of its relative and absolute stereochemistry.
Synthesis of a malimide analogue of the telomerase inhibitor UCS1025A using a dianionic aldol strategy
De Figueiredo, Renata Marcia,Voith, Matthias,Fr?hlich, Roland,Christmann, Mathias
, p. 391 - 394 (2008/01/03)
The synthesis of a simplified analogue of UCS1025A via an aldol coupling is described. Georg Thieme Verlag Stuttgart.
