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86483-43-4

4,5-Dichloro-2-(3,5-dichlorophenyl)-2,3-dihydropyridazin-3-one is a chemical compound with the molecular formula C12H6Cl4N2O. It is a white crystalline solid that possesses unique structure and pharmacological properties, making it a promising candidate for various applications in the pharmaceutical industry.
Used in Pharmaceutical Industry:
4,5-Dichloro-2-(3,5-dichlorophenyl)-2,3-dihydropyridazin-3-one is used as an intermediate in the synthesis of various drugs. Its unique structure and pharmacological properties contribute to the development of new drugs with potential therapeutic benefits.
Used in Medicinal Chemistry Research:
4,5-Dichloro-2-(3,5-dichlorophenyl)-2,3-dihydropyridazin-3-one is used as a subject of research in the field of medicinal chemistry. Its properties and potential uses are being investigated to explore its applications in drug development and other related fields.
It is important to handle 4,5-Dichloro-2-(3,5-dichlorophenyl)-2,3-dihydropyridazin-3-one with care and follow all safety guidelines when working with it in a laboratory setting to ensure the safety of researchers and the integrity of the experiments. Further research on its properties and potential uses is ongoing, and it holds promise for future applications in drug development and other fields.

86483-43-4

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86483-43-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 86483-43-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,4,8 and 3 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 86483-43:
(7*8)+(6*6)+(5*4)+(4*8)+(3*3)+(2*4)+(1*3)=164
164 % 10 = 4
So 86483-43-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H4Cl4N2O/c11-5-1-6(12)3-7(2-5)16-10(17)9(14)8(13)4-15-16/h1-4H

86483-43-4 Well-known Company Product Price

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  • Alfa Aesar

  • (B25651)  4,5-Dichloro-2-(3,5-dichlorophenyl)-3(2H)-pyridazinone, 97%   

  • 86483-43-4

  • 1g

  • 384.0CNY

  • Detail

  • Alfa Aesar

  • (B25651)  4,5-Dichloro-2-(3,5-dichlorophenyl)-3(2H)-pyridazinone, 97%   

  • 86483-43-4

  • 5g

  • 1531.0CNY

  • Detail

86483-43-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 4,5-dichloro-2-(3,5-dichlorophenyl)pyridazin-3-one

1.2 Other means of identification

Product number -
Other names 4,5-dichloro-2-(3,5-dichlorophenyl)-2,3-dihydropyridazin-3-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:86483-43-4 SDS

86483-43-4Relevant articles and documents

The synthesis and structure-activity relationship of pyridazinones as glucan synthase inhibitors

Ting, Pauline C.,Kuang, Rongze,Wu, Heping,Aslanian, Robert G.,Cao, Jianhua,Kim, David W.,Lee, Joe F.,Schwerdt, John,Zhou, Gang,Wainhaus, Samuel,Black, Todd A.,Cacciapuoti, Anthony,McNicholas, Paul M.,Xu, Yiming,Walker, Scott S.

scheme or table, p. 1819 - 1822 (2011/05/05)

A structure-activity relationship study of the lead 5-[4-(benzylsulfonyl) piperazin-1-yl]-4-morpholino-2-phenyl-pyridazin-3(2H)-one 1 has resulted in the identification of 2-(3,5-difluorophenyl)-4-(3-fluorocyclopentyloxy)-5-[4- (isopropylsulfonyl)piperazin-1-yl]-pyridazin-3(2H)-one 11c as a β-1,3-glucan synthase inhibitor. Compound 11c exhibited significant efficacy in an in vivo mouse model of Candida glabrata infection.

Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors

Suree, Nuttee,Yi, Sung Wook,Thieu, William,Marohn, Melanie,Damoiseaux, Robert,Chan, Albert,Jung, Michael E.,Clubb, Robert T.

experimental part, p. 7174 - 7185 (2010/03/30)

Methicillin resistant Staphylococcus aureus (MRSA) is a major health problem that has created a pressing need for new antibiotics. Compounds that inhibit the S. aureus SrtA sortase may function as potent anti-infective agents as this enzyme attaches virulence factors to the cell wall. Using high-throughput screening, we have identified several compounds that inhibit the enzymatic activity of the SrtA. A structure-activity relationship (SAR) analysis led to the identification of several pyridazinone and pyrazolethione analogs that inhibit SrtA with IC50 values in the sub-micromolar range. Many of these molecules also inhibit the sortase enzyme from Bacillus anthracis suggesting that they may be generalized sortase inhibitors.

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