86483-43-4 Usage
General Description
4,5-Dichloro-2-(3,5-dichlorophenyl)-2,3-dihydropyridazin-3-one is a chemical compound with the molecular formula C12H6Cl4N2O. It is a white crystalline solid that is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. 4,5-DICHLORO-2-(3,5-DICHLOROPHENYL)-2,3-DIHYDROPYRIDAZIN-3-ONE has potential applications in the field of medicinal chemistry due to its unique structure and pharmacological properties. It is important to handle this chemical with care and follow all safety guidelines when working with it in a laboratory setting. Further research on its properties and potential uses is ongoing, and it holds promise for future applications in drug development and other fields.
Check Digit Verification of cas no
The CAS Registry Mumber 86483-43-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,4,8 and 3 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 86483-43:
(7*8)+(6*6)+(5*4)+(4*8)+(3*3)+(2*4)+(1*3)=164
164 % 10 = 4
So 86483-43-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H4Cl4N2O/c11-5-1-6(12)3-7(2-5)16-10(17)9(14)8(13)4-15-16/h1-4H
86483-43-4Relevant articles and documents
The synthesis and structure-activity relationship of pyridazinones as glucan synthase inhibitors
Ting, Pauline C.,Kuang, Rongze,Wu, Heping,Aslanian, Robert G.,Cao, Jianhua,Kim, David W.,Lee, Joe F.,Schwerdt, John,Zhou, Gang,Wainhaus, Samuel,Black, Todd A.,Cacciapuoti, Anthony,McNicholas, Paul M.,Xu, Yiming,Walker, Scott S.
scheme or table, p. 1819 - 1822 (2011/05/05)
A structure-activity relationship study of the lead 5-[4-(benzylsulfonyl) piperazin-1-yl]-4-morpholino-2-phenyl-pyridazin-3(2H)-one 1 has resulted in the identification of 2-(3,5-difluorophenyl)-4-(3-fluorocyclopentyloxy)-5-[4- (isopropylsulfonyl)piperazin-1-yl]-pyridazin-3(2H)-one 11c as a β-1,3-glucan synthase inhibitor. Compound 11c exhibited significant efficacy in an in vivo mouse model of Candida glabrata infection.
