86483-54-7

Usage

Uses

Used in Pharmaceutical Industry:
7-CHLORO-1-CYCLOPROPYL-6-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER is used as a reagent in the preparation of anti-HIV agents for its potential to combat viral infections, particularly HIV. Its role in the development of new therapeutic agents highlights its importance in the ongoing fight against HIV/AIDS.
Used in Antiviral Research:
In the field of antiviral research, 7-CHLORO-1-CYCLOPROPYL-6-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER serves as a valuable compound for studying the mechanisms of action against HIV and other viral pathogens. Its unique structure and properties make it a promising candidate for further investigation and development into effective antiviral treatments.

Upstream product

• 16173-58-3 N,N-dimethylaminoacrylic acid ethyl ester 
• 37026-85-0 tri-n-butylammonium bromide 
• 86393-34-2 2,4-dichloro-5-fluorobenzoyl chloride 
• 765-30-0 Cyclopropylamine 

Downstream Products

• 93107-08-5 ciprofloxacin hydrochloride 
• 1412409-69-8 ethyl 1-cyclopropyl-7-((2S,2'S,5R,5'R)-5,5'-dibenzyl-2,2'-bimorpholino)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 1375100-76-7 3-((4-nitrobenzylidene)hydrazinecarbonyl)-7-(N'-(4-nitrobenzylidene)hydrazino)-1-cycloproyl-6-fluoroquinolin-4(1H)-one 
• 1375100-75-6 3-((4-fluorobenzylidene)hydrazinocarbonyl)-7-(N'-(4-fluorobenzylidene)hydrazino)-1-cycloproyl-6-fluoroquinolin-4(1H)-one 
• 1375100-74-5 3-((3-hydroxy-4-methoxybenzylidene)hydrazinocarbonyl)-7-(N'-(3-hydroxy-4-methoxybenzylidene)hydrazino)-1-cycloproyl-6-fluoroquinolin-4(1H)-one 
• 1375100-73-4 3-((3,4,5-trimethoxybenzylidene)hydrazinocarbonyl)-7-(N'-(3,4,5-trimethoxybenzylidene)hydrazino)-1-cycloproyl-6-fluoroquinolin-4(1H)-one 
• 1375100-71-2 3-((4-methoxybenzylidene)hydrazinocarbonyl)-7-(N'-(4-methoxybenzylidene) hydrazino)-1-cycloproyl-6-fluoroquinolin-4(1H)-one 
• 1375100-70-1 3-((2-hydroxybenzylidene)hydrazinocarbonyl)-7-(N'-(2-hydroxybenzylidene)hydrazino)-1-cycloproyl-6-fluoroquinolin-4(1H)-one 
• 1375100-69-8 3-(benzylidenehydrazinocarbonyl)-7-(N'-benzylidenehydrazino)-1-cycloproyl-6-fluoroquinolin-4(1H)-one 
• 93106-60-6 enrofloxacin 
• 85721-33-1 ciprofloxacin 
• 86393-33-1 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid 

Relevant academic research and scientific papers

Process for preparing quinolone- and naphthyridone- carboxylic acids and esters thereof

An improved process for preparing quinolone- and naphthyridonecarboxylic acids and esters thereof from benzoyl chlorides and nicotinoyl chlorides, respectively, in which the reaction carried out in the presence of a non-polar to slightly polar solvent without separation of intermediaries that form during the process.

Cycloaracylation of Enamines, I. - Synthesis of 4-Quinolone-3-carboxylic Acids

Starting with o-halobenzoyl chlorides 4 and open-chain secondary enamines 5, a new synthesis of 4-quinolone-3-carboxylic acids 12 is described.The reaction of 7-haloquinolone-3-carboxylic acids 12a-k with aliphatic amines 14 produces highly active antibacterial 7-aminoquinolone-3-carboxylic acids 15.The main product of the 1-cyclopropyl series, "ciprofloxacin" (15a), is being developed as a broad-spectrum chemotherapeutic agent.