864866-92-2

Basic information

• Product Name: 1(2H)-Isoquinolinone,6-bromo-2-methyl-(9CI)
• Synonyms: 1(2H)-Isoquinolinone,6-bromo-2-methyl-(9CI);6-Bromo-2-methylisoquinolin-1(2H)-one;6-broMo-2-Methyl-1,2-dihydroisoquinolin-1-one;6-Bromo-2-methyl-2H-isoquinolin-1-one;6-Bromo-2-methylisoquinolin-1(2H)
• CAS NO: 864866-92-2
• Molecular Formula: C10H8BrNO
• Molecular Weight: 238.083
• Product Categories: QUINOLINONE
• Mol File: 864866-92-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 373°C at 760 mmHg
• Flash Point: 179.4°C
• Appearance: /
• Density: 1.553g/cm³
• Vapor Pressure: 9.23E-06mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -2.50±0.70(Predicted)
• CAS DataBase Reference: 1(2H)-Isoquinolinone,6-bromo-2-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Isoquinolinone,6-bromo-2-methyl-(9CI)(864866-92-2)
• EPA Substance Registry System: 1(2H)-Isoquinolinone,6-bromo-2-methyl-(9CI)(864866-92-2)

Safety Data

• Hazardous Substances Data: 864866-92-2(Hazardous Substances Data)

Usage

General Description

1(2H)-Isoquinolinone,6-bromo-2-methyl-(9CI) is a chemical compound with the molecular formula C10H8BrNO. It is an isoquinolinone derivative with a bromine atom at the 6th position and a methyl group at the 2nd position. 1(2H)-Isoquinolinone,6-bromo-2-methyl-(9CI) has potential applications in the field of organic synthesis and medicinal chemistry due to its unique structure and reactivity. It can be used as a building block for the synthesis of various organic compounds and pharmaceuticals. Additionally, its functional groups make it a valuable intermediate in the production of diverse chemical products. 1(2H)-Isoquinolinone,6-bromo-2-methyl-(9CI) is of interest to researchers and chemists for its potential applications in the development of new drugs and materials.

InChI:InChI=1/C10H8BrNO/c1-12-5-4-7-6-8(11)2-3-9(7)10(12)13/h2-6H,1H3

Upstream product

• 74-88-4 methyl iodide 
• 82827-09-6 6-bromo-2H-isoquinoline-1-one 
• 34784-05-9 6-bromo-isoquinoline 

Relevant articles and documents

Identification of 2-Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c-KIT

Herein, we report two promising compounds 30 and 36 possessing nanomolar FLT3 inhibitory activities (IC50 = 1.5-7.2 nM), high selectivity over c-KIT (>1000-fold), and excellent anti-AML activity (MV4-11 IC50 = 0.8-3.2 nM). Furthermore, these two compounds efficiently inhibited the growth of multiple mutant BaF3 cells expressing FLT3-ITD, FLT3-D835V/F, FLT3-F691L, FLT3-ITD-F691L, and FLT3-ITD-D835Y. Oral administration of 30 and 36 at 6 mg/kg/d could significantly suppress tumor growth in the MV4-11 cell-inoculated xenograft model, exhibiting tumor growth inhibitory rates of 83.5% and 95.1%, respectively. Importantly, 36 could prolong the mouse survival time in the FLT3-ITD-TKD dual mutation syngeneic mouse model (BaF3-FLT3-ITD-D835Y) at a dose of 6 mg/kg p.o. bid/4W. No clear myelosuppression was observed in the treated group of 36 in the MPO strain of zebrafish, even at 10 μM. In summary, our data demonstrated that 36 may represent a promising candidate for the treatment of FLT3 mutant AML.

Covalent Organic Frameworks toward Diverse Photocatalytic Aerobic Oxidations

Photoactive two-dimensional covalent organic frameworks (2D-COFs) have become promising heterogenous photocatalysts in visible-light-driven organic transformations. Herein, a visible-light-driven selective aerobic oxidation of various small organic molecules by using 2D-COFs as the photocatalyst was developed. In this protocol, due to the remarkable photocatalytic capability of hydrazone-based 2D-COF-1 on molecular oxygen activation, a wide range of amides, quinolones, heterocyclic compounds, and sulfoxides were obtained with high efficiency and excellent functional group tolerance under very mild reaction conditions. Furthermore, benefiting from the inherent advantage of heterogenous photocatalysis, prominent sustainability and easy photocatalyst recyclability, a drug molecule (modafinil) and an oxidized mustard gas simulant (2-chloroethyl ethyl sulfoxide) were selectively and easily obtained in scale-up reactions. Mechanistic investigations were conducted using radical quenching experiments and in situ ESR spectroscopy, all corroborating the proposed role of 2D-COF-1 in photocatalytic cycle.

N2-carbamylaryl-2-aminopyrimidine derivative and medical application thereof

The invention provides an N2-carbamylaryl-2-aminopyrimidine derivative and a medical application thereof. The N2-carbamylaryl-2-aminopyrimidine derivative provided by the invention comprises an optical isomer of the N2-carbamylaryl-2-aminopyrimidine derivative and pharmaceutically acceptable salt thereof. Pharmacodynamic research shows that the traditional Chinese medicine composition has no toxicor side effect, the compound has an FLT3 inhibitory activity. The proliferation inhibition activity is realized on various leukemia cell strains; a medium inhibition effect is achieved on breast cancer cells; moreover, the polypeptide is effective for multiple mutations of AML, such as internal tandem repeat mutation of a near-membrane structural domain and D835 point mutation of an activated ring in a kinase structural domain, almost has no inhibition effect on c-KIT, can overcome drug resistance brought by clinical point mutation, can reduce toxic and side effects of bone marrow inhibition,and can be applied to preparation of antitumor drugs. The structures of the general formulas Ia and Ib of the N2-carbamylaryl-2-aminopyrimidine derivative are shown in the specification,