865444-90-2Relevant articles and documents
Methods for synthesizing imidazotriazinones
-
Page/Page column 6; 10, (2008/06/13)
Methods of synthesizing imidazotriazinones, such as vardenafil, and compositions useful for the same are disclosed.
A novel method for the synthesis of imidazo[5,1-f][1,2,4]triazin-4(3H)-ones
Heim-Riether, Alexander,Healy, Jason
, p. 7331 - 7337 (2007/10/03)
Imidazo[5,1-f][1,2,4]triazinones, as isosteres of purine, are of interest for pharmaceutical research. The syntheses reported in the literature generally require several steps. We report a novel method to access a broad range of diversely substituted derivatives. The key step is the electrophilic N-amination of 3H-imidazoles containing a 4-carbonyl group. Several different substituted imidazoles have been N-aminated in this manner. The resulting N-aminoimidazoles were cyclized under different conditions to the corresponding imidazotriazinones, which allowed for additional diversification. This novel method was applied in a formal synthesis of vardenafil, a well-known representative of this class of compounds. Furthermore, we report the first synthesis of a 7-aryl-imidazotriazinone via bromination of an unsubstituted imidazotriazinone followed by a Suzuki coupling.
