86547-30-0

Upstream product

• 56-45-1 L-serin 
• 37504-92-0 (4'S)-(2',2',5',5'-tetramethyl-1',3'-dioxolan-4'-yl)methanol 
• 86547-27-5 Benzoesaeure-<((4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methyl>ester 
• 86547-26-4 Benzoesaeure-<(2S)-2,3-dihydroxy-3-methylbutyl>ester 
• 86562-72-3 S(-)methyl-3 butanetriol-1,2,3 
• 86562-71-2 2-<(S)-2,2-dimethyl-1,3-dioxolane-4-yl>-2-propanol 
• 37504-94-2 p-Toluolsulfonsaeure-<((4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methyl>ester 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 954409-30-4 2-({4-chloro-2-[(3-chloro-5-cyanophenyl)carbonyl]phenyl}oxy)-N-(4-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-2-methylphenyl)acetamide 
• 954409-36-0 (2S)-3-methyl-1-[(3-methyl-4-nitrophenyl)oxy]-2,3-butanediol 
• 954409-38-2 (2S)-1-[(4-amino-3-methylphenyl)oxy]-3-methyl-2,3-butanediol 
• 37504-94-2 p-Toluolsulfonsaeure-<((4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methyl>ester 
• 1093988-29-4 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)phenyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 
• 1093988-31-8 4-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)benzohydrazide 
• 1093988-30-7 methyl 4-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)benzoate 
• 1093988-73-8 2-chloro-4-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)benzohydrazide 
• 1093988-72-7 methyl 2-chloro-4-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)benzoate 
• 1093988-66-9 2-methyl-4-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)benzohydrazide 
• 1093988-65-8 methyl 2-methyl-4-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)benzoate 
• 1093988-32-9 3-chloro-5-[(6-chloro-3-{[5-(4-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}phenyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 
• 239100-42-6 (1R,3aR,4S,7aR,1S)-7a-methyl-1-[(1S,2RS,4S)-4,5-dihydroxy-1,5-dimethyl-2-(phenylsulphonyl)hexyl]octahydro-1H-inden-4-ol 

Relevant academic research and scientific papers

CHEMICAL COMPOUNDS

The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.

d- and l-Serine, useful synthons for the synthesis of 24-hydroxyvitamin D3 metabolites. A formal synthesis of 1α,24R,25-(OH)3-D3, 24R,25-(OH)2-D3 and 24S,25-(OH)2-D3

d- and l-Serine have been used for the enantioselective synthesis of tosylates 7a and 7b, useful building blocks for the synthesis of triols 5a and 5b which have already been obtained via a diastereoselective synthesis and used for the synthesis of 2a, 2b and 2c. We have thus performed a formal synthesis of 24S,25-(OH)2-D3, 24R,25-(OH)2-D3 and 1α,24R,25-(OH)3-D3.

Synthesis and Determination of the Enantiomeric Pyrity of (R)- and (S)-2,3-Dihydroxy-3-methylbutyl p-Toluensulfonate

(R)- and (S)-2,3-dihydroxy-3-methylbutyl p-toluenesulfonate, used as building blocks for vitamine D3 metabolites and carotenoids, respectively, were resynthesized since differing melting points and optical rotations are reported in the literature.The give

Optically Active C5-Synthons for the Synthesis of Naturally Occurring Terpenes

The optically active synthons (S)-22, (R)-23, (R)-25 and (R)-26 were prepared from L-serine.Furthermore the tertiary alcohol 6 was synthesized from L-serine (-> (S)-6) and D-mannitol (-> (R)-6).These compounds are suitable for the synthesis of optically active natural products.