86562-71-2

Basic information

• Product Name: 2-<(S)-2,2-dimethyl-1,3-dioxolane-4-yl>-2-propanol
• CAS NO: 86562-71-2
• Molecular Weight: 160.213
• Mol File: 86562-71-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-<(S)-2,2-dimethyl-1,3-dioxolane-4-yl>-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-<(S)-2,2-dimethyl-1,3-dioxolane-4-yl>-2-propanol(86562-71-2)
• EPA Substance Registry System: 2-<(S)-2,2-dimethyl-1,3-dioxolane-4-yl>-2-propanol(86562-71-2)

Safety Data

• Hazardous Substances Data: 86562-71-2(Hazardous Substances Data)

Usage

Functional Groups

Alcohol (-OH): Provides reactivity in organic synthesis.
Dioxolane Ring (1,3-dioxolane): A six-membered heterocyclic ring consisting of five carbon atoms and one oxygen atom, enhancing solubility and stability.
Methyl Groups (-CH3): Two methyl groups attached, contributing to steric effects and influencing properties like boiling point and solubility.
Isopropyl Group (-C3H7): Enhances solubility and can influence reactivity in chemical reactions.

Application

Solvent: Widely used as a solvent in various industries due to its ability to dissolve a wide range of substances.
Reagent: Can serve as a reagent in organic synthesis reactions, contributing to the formation of various organic compounds.

Versatility

The compound's structure and functional groups make it adaptable for numerous applications in different industries.

Properties

Solubility: Soluble in many organic solvents and water.
Boiling Point: The presence of functional groups affects the boiling point, typically higher than simpler alcohols due to increased molecular weight and complexity.
Stability: The dioxolane ring contributes to stability, making the compound less prone to decomposition under certain conditions.

Common Use Cases

Industrial solvents, pharmaceutical synthesis, organic chemistry reactions.

Upstream product

• 917-54-4 methyllithium 
• 60456-21-5 methyl (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 110548-95-3 evoxine 
• 77-76-9 2,2-dimethoxy-propane 
• 75-16-1 methylmagnesium bromide 
• 917-64-6 methyl magnesium iodide 

Downstream Products

• 1093988-29-4 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)phenyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 
• 1093988-31-8 4-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)benzohydrazide 
• 1093988-66-9 2-methyl-4-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)benzohydrazide 
• 1093988-65-8 methyl 2-methyl-4-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)benzoate 
• 1093988-32-9 3-chloro-5-[(6-chloro-3-{[5-(4-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}phenyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 
• 1094342-09-2 3-chloro-5-[(6-chloro-3-{[5-(2-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-5-methyl-4-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 
• 1094345-89-7 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[5-methyl-2-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-4-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 
• 1094345-86-4 N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-5-methyl-2-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-4-pyridinecarbohydrazide 
• 1094345-84-2 N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-2-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-5-methyl-4-pyridinecarbohydrazide 
• 1094342-08-1 3-chloro-5-[(6-chloro-3-{[5-(6-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-4-methyl-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 
• 1094342-07-0 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 
• 1094342-50-3 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-2-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-1,3-thiazol-5-yl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 
• 1094342-48-9 3-chloro-5-[(6-chloro-3-{[5-(6-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-2-methyl-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 
• 1094342-45-6 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[2-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 

Relevant articles and documents

4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS

Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

CHEMICAL COMPOUNDS

The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.

d- and l-Serine, useful synthons for the synthesis of 24-hydroxyvitamin D3 metabolites. A formal synthesis of 1α,24R,25-(OH)3-D3, 24R,25-(OH)2-D3 and 24S,25-(OH)2-D3

d- and l-Serine have been used for the enantioselective synthesis of tosylates 7a and 7b, useful building blocks for the synthesis of triols 5a and 5b which have already been obtained via a diastereoselective synthesis and used for the synthesis of 2a, 2b and 2c. We have thus performed a formal synthesis of 24S,25-(OH)2-D3, 24R,25-(OH)2-D3 and 1α,24R,25-(OH)3-D3.