86559-21-9Relevant academic research and scientific papers
A direct conversion of alkenes to isocyanides
Kitano, Yoshikazu,Chiba, Kazuhiro,Tada, Masahiro
, p. 288 - 290 (1999)
Treatment of alkenes with silver salts (AgClO4, AgBF4, or AgOTf) and trimethylsilyl cyanide (TMSCN) in dichloromethane followed by hydrolysis affords the corresponding isocyanides directly in high yields. The addition of the isocyano function is carried out in accordance with Markovnikov's rule.
A direct conversion of alcohols to isocyanides
Kitano, Yoshikazu,Chiba, Kazuhiro,Tada, Masahiro
, p. 1911 - 1912 (2007/10/03)
A new method for the preparation of the isocyanide group is described. Treatment of alcohols with zinc reagents (ZnI2, ZnBr2, or ZnCl2) and trimethylsilyl cyanide (TMSCN) in dichloromethane followed by desilylation with tetrabutylammoniium fluoride (TBAF) affords the corresponding isocyanides directly in good yields.
