86607-73-0

Basic information

• Product Name: 2-Bromo-4'-formyldiphenyl ether
• Synonyms: 2-Bromo-4'-formyldiphenyl ether;Benzaldehyde, 4-(2-bromophenoxy)-
• CAS NO: 86607-73-0
• Molecular Formula: C₁₃H₉BrO₂
• Molecular Weight: 277.11336
• Mol File: 86607-73-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Bromo-4'-formyldiphenyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4'-formyldiphenyl ether(86607-73-0)
• EPA Substance Registry System: 2-Bromo-4'-formyldiphenyl ether(86607-73-0)

Safety Data

• Hazardous Substances Data: 86607-73-0(Hazardous Substances Data)

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 555-16-8 4-nitrobenzaldehdye 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 1398090-13-5 C₃₀H₂₄Br₃F₂NO₃ 
• 1398090-58-8 C₂₃H₂₀Br₃NO₃ 
• 1398089-62-7 2-(3,5-dibromo-4-((4-(2-bromophenoxy)benzyl)(3,5-difluorobenzyl)amino)phenyl)acetic acid 
• 86607-82-1 2-hydroxymethyl-dibenzo[b,d]furan 
• 639517-90-1 (2Z)-2-(benzoylamino)-3-[4-(2-bromophenoxy)phenyl]prop-2-enoic acid 
• 1055425-08-5 (Z)-2-Benzoylamino-3-[4-(2-bromo-phenoxy)-phenyl]-acrylic acid methyl ester 
• 86607-78-5 2-Bromo-4'-hydroxymethyldiphenyl ether 

Relevant articles and documents

Acyl radical smiles rearrangement to construct hydroxybenzophenones by photoredox catalysis

The first visible-light-induced acyl radical Smiles rearrangement to transform biaryl ethers to hydroxybenzophenones under mild and metal-free conditions is reported. Using the dual catalysis of hypervalent iodine(III) reagents and organophotocatalysts, ketoacids readily generate acyl radicals and undergo 1,5-ipso addition. This method can construct electron-deficient and electron-rich hydroxybenzophenones with excellent chemoselectivity and on gram scale. The performance of the reaction in neutral aqueous conditions holds potential for future biomolecule applications.

Highly efficient heterogeneous copper-catalysed O-arylation of phenols by nitroarenes leading to diaryl ethers

The heterogeneous O-arylation of phenols by nitroarenes was achieved in DMF at 100 °C by using an MCM-41-immobilised bidentate nitrogen copper(II) complex [MCM-41-2N-Cu(OAc)2] as catalyst, yielding a variety of unsymmetrical diaryl ethers in good to excellent yields. This heterogeneous copper catalyst can be easily prepared by a simple procedure from commercially readily available and inexpensive reagents, recovered by filtration of the reaction solution and recycled at least seven times without significant loss of activity.

Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid

A novel series of nonnucleoside HCV NS5B polymerase inhibitors were prepared from (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid, a high throughput screening lead. SAR studies combined with structure based drug design focusing on the southern heterobiaryl region of the template led to the synthesis of several potent and orally bioavailable lead compounds. X-ray crystallography studies were also performed to understand the interaction of these inhibitors with HCV NS5B polymerase.