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Usage

Uses

Used in Pharmaceutical Industry:
2-METHYL-4-(METHYLAMINO)BUTAN-2-OL is used as a pharmaceutical intermediate for the synthesis of various pharmaceuticals and organic compounds. Its unique chemical structure and properties make it a valuable component in the development of new drugs and medications.
Used in Chemical Industry:
2-METHYL-4-(METHYLAMINO)BUTAN-2-OL is also used as an organic building block in the chemical industry. Its versatility and solubility in water make it a useful component in the synthesis of a wide range of organic compounds for various applications.

InChI:InChI=1/C6H15NO/c1-6(2,8)4-5-7-3/h7-8H,4-5H2,1-3H3

Upstream product

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Relevant academic research and scientific papers

Carbanion-accelerated claisen rearrangements: Asymmetric induction with chiral phosphorus-stabilized anions

The carbanion-accelerated Claisen rearrangement has been extended to include phosphorus carbanion-stabilizing groups. The appropriately substituted allyl vinyl ethers are synthesized by the nucleophilic addition of allyl oxides to phosphorus-substituted allenes, which are obtained in one step from simple starting materials. The phosphorus-stabilized, carbanion-accelerated Claisen rearrangements proceed rapidly at room temperature in high yield, and the rearrangements are highly site- and stereoselective. The first examples of asymmetric induction in the Claisen rearrangement with chiral, phosphorus, anion-stabilizing groups are described. The observed asymmetric induction is highly dependent on the structure of the auxiliary and the metal counterion involved. Both internal and relative diastereoselectivity are high. A model for the observed sense of internal diastereoselectivity is proposed that is founded in the current understanding of the structure of phosphorus-stabilized anions.