866412-75-1Relevant academic research and scientific papers
Synthesis of deserpidine from reserpine
Varchi, Greta,Battaglia, Arturo,Samori, Cristian,Baldelli, Eleonora,Danieli, Bruno,Fontana, Gabriele,Guerrini, Andrea,Bombardelli, Ezio
, p. 1629 - 1631 (2005)
The Rauwolfia alkaloids reserpine (1) and deserpidine (2), two alkaloids from Rauwolfia species, have been widely used for their antihypertensive action. Deserpidine (2) is a compound with limited availability from natural sources, and its synthesis from 1 in six steps (41% overall yield) is reported here.
A PROCESS FOR THE SEMISYNTHESIS OF DESERPIDINE
-
Page/Page column 8-9, (2010/02/14)
The present invention relates to an efficient procedure for the synthesis of deserpidine (Ia), starting from reserpic acid lactone (II) via the intermediate 11-O-demethyl reserpic acid lactone (III).
