866412-83-1

Upstream product

• 6773-29-1 dimethyl diazomalonate 
• 10147-11-2 propargyl benzene 
• 33992-52-8 (3-bromopropa-1,2-dien-1-yl)benzene 
• 108-59-8 malonic acid dimethyl ester 
• 2327-99-3 1-phenylpropadiene 

Downstream Products

• 1221134-04-8 (Z)-dimethyl 2-(3-phenylallylidene)malonate 
• 1221134-14-0 (E)-methyl 2-benzylidene-1-pentanoylcyclopropanecarboxylate 
• 1263816-67-6 (E)-dimethyl 2-(3-(benzyl(prop-2-ynyl)amino)-1-phenylprop-1-en-2-yl)malonate 
• 1263816-68-7 dimethyl (E)-2-(3-ethoxy-1-phenylprop-1-en-2-yl)malonate 
• 1089186-41-3 dimethyl 2-(1H-inden-2-yl)malonate 
• 1263816-45-0 dimethyl (E)-2-(1-phenyl-3-(prop-2-ynyloxy)prop-1-en-2-yl)malonate 
• 1263816-72-3 dimethyl (E)-3-benzylidene-5-methylene-tetrahydropyran-4,4-dicarboxylate 
• 1263816-70-1 dimethyl (E)-2-(3-isopropoxy-1-phenylprop-1-en-2-yl)malonate 
• 1263816-63-2 dimethyl (E)-2-(3-(but-3-yn-2-yloxy)-1-phenylprop-1-en-2-yl)malonate 
• 1263816-82-5 dimethyl (E)-5-benzylidene-2-methyl-3-methylene-tetrahydropyran-4,4-dicarboxylate 
• 1263816-65-4 dimethyl (E)-2-(3-(but-3-ynyloxy)-1-phenylprop-1-en-2-yl)malonate 

Relevant academic research and scientific papers

Intermolecular tandem addition-cyclization of bromoallenes: A facile synthesis of methylenecyclopropyl carboxylates and polysubstituted furans

(Chemical Equation Presented) The base-mediated reactions of 1,3-dicarbonyl compounds with bromoallenes used as an allyl dication equivalent were explored. The corresponding dimethyl methylenecyclopropane-1,1-dicarboxylates and 2,3,4-trisubstituted furans

An efficient stereoselective synthesis of 4,5-trans-1,5-cis-3-oxabicyclo[3. 1.0]hexan-2-ones via the iodolactonization of alkylidenecyclopropyl esters

A highly stereoselective iodolactonization of alkylidenecyclopropyl esters with iodine or N-iodosuccinimide (NIS) in aqueous CH3CN to afford 4,5-trans-1,5-cis-3-oxabicyclo-[3.1.0]hexane-2-ones is described. The reaction is very general, accommodating a wide range of substituents. A plausible mechanism that explains the essential role of water in this reaction is proposed.

Catalytic, formal homo-Nazarov-type cyclizations of alkylidene cyclopropane-1,1-ketoesters: Access to functionalized arenes and heteroaromatics

A catalytic, formal homo-Nazarov-type cyclization of alkylidene cyclopropanes (ACPs) to give functionalized arenes and heteroaromatics is reported. In the presence of a Lewis acid catalyst, the ACP 1,1-ketoesters undergo distal bond cleavage to afford an allyl cation intermediate. Adjacent π-attack on the allyl cation then provides a six-membered ring that undergoes rapid aromatization. In these cases, benzenoid products are formed in up to 98% yield. Strategic choice of the substitution about the ACP allows for the generation of other useful isomeric products in good yields.

DBU-mediated transformation of arylmethylenecyclopropenes to alkylidenecyclopropanes

An interesting DBU-mediated intramolecular isomerization of arylmethylenecyclopropenes 1 to alkylidenecyclopropanes (ACPs) has been described in this context. A variety of ACPs were obtained through a base-assisted manner in moderate to good yields under mild conditions with good stereoselectivities in most cases.