866453-60-3

Basic information

• Product Name: 4-[[(6S)-6-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-1,3,4,5,6,7-hexahydro-2,2-dioxidobenzo[c]thien-1-yl]Methylene]octahydro-α,7a-diMethyl-1H-indene-1-acetaldehyde
• Synonyms: 4-[[(6S)-6-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-1,3,4,5,6,7-hexahydro-2,2-dioxidobenzo[c]thien-1-yl]Methylene]octahydro-α,7a-diMethyl-1H-indene-1-acetaldehyde
• CAS NO: 866453-60-3
• Molecular Formula: C₂₈H₄₆O₄SSi
• Molecular Weight: 506.81294
• Product Categories: Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 866453-60-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[[(6S)-6-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-1,3,4,5,6,7-hexahydro-2,2-dioxidobenzo[c]thien-1-yl]Methylene]octahydro-α,7a-diMethyl-1H-indene-1-acetaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[[(6S)-6-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-1,3,4,5,6,7-hexahydro-2,2-dioxidobenzo[c]thien-1-yl]Methylene]octahydro-α,7a-diMethyl-1H-indene-1-acetaldehyde(866453-60-3)
• EPA Substance Registry System: 4-[[(6S)-6-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-1,3,4,5,6,7-hexahydro-2,2-dioxidobenzo[c]thien-1-yl]Methylene]octahydro-α,7a-diMethyl-1H-indene-1-acetaldehyde(866453-60-3)

Safety Data

• Hazardous Substances Data: 866453-60-3(Hazardous Substances Data)

Usage

Uses

4-[[(6S)-6-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1,3,4,5,6,7-hexahydro-2,2-dioxidobenzo[c]thien-1-yl]methylene]octahydro-α,7a-dimethyl-1H-indene-1-acetaldehyde is an intermediate in the synthesis of Secalciferol (S211500), metabolite of Vitamin D, a possible anti-inflammatory steroid.

Upstream product

• 50-14-6 Calciferol 
• 170081-43-3 SO2-adduct of 3(S)-<(tert-butyldimethylsilyl)oxy>-9,10-secoergosta-5,7(E),10(19),22(E)-tetraene 

Downstream Products

• 112828-12-3 3(R)-(tert-butyldimethylsilyloxy)-20(S)-formyl-9,10-secopregna-5(Z),7(E),10⁽¹⁹⁾-triene 
• 344798-31-8 3(S)-<(tert-butyldimethylsilyl)oxy>-20(S)-(hydroxymethyl)-9,10-secopregna-5(Z),7(E),10(19)-triene SO2 adduct 
• 344798-32-9 3(S)-<(tert-butyldimethylsilyl)oxy>-20(S)-(iodomethyl)-9,10-secopregna-5(Z),7(E),10(19)-triene SO2 adduct 
• 170081-45-5 3(S)-<(tert-butyldimethylsilyl)oxy>-20(S)-(iodomethyl)-9,10-secopregna-5(E),7(E),10(19)-triene 
• 58050-56-9 C₂₈H₄₄O₂ 
• 120707-37-1 24(S)-hydroxyvitamin D₂ 

Relevant articles and documents

Site-selective modification of vitamin D analogue (Deltanoid) through a resin-based version of organoselenium 2,3-sigmatropic rearrangement

Figure Presented. A site-selective modification of a vitamin D analogue (Deltanoid) through a two-step 2,3-sigmatropic rearrangement of organoselenium resin to prepare the key intermediate of calcipotriol has been developed. The polystyrene-supported sele

A stereospecific synthesis of 24(S)-hydroxyvitamin D2, a prodrug for 1α,24(S)-dihydroxyvitamin D2

This contribution describes the first stereospecific synthesis of 24(S)-hydroxyvitamin D2 (1), a metabolite of vitamin D2. This metabolite acts as a prodrug for 1α,24(S)-dihydroxyvitamin D2 (2), which is under development for treatment of various diseases characterized by cellular hyperproliferation. The key step of the synthesis involves the Wittig-Horner olefination of (S)-2,3-dimethyl-2-triethysilyloxybutyraldehyde (17) and a vitamin D2 phosphine oxide derivative (22). The synthesis of the requisite aldehyde started with the commercially available L-(+)-valine and was completed in seven steps. The vitamin D2 phosphine oxide derivative was synthesized in seven steps starting from vitamin D2.