120707-37-1

Basic information

• Product Name: 24(S)-hydroxyvitamin D₂
• Synonyms: 24(S)-hydroxyvitamin D₂
• CAS NO: 120707-37-1
• Molecular Weight: 412.656
• Mol File: 120707-37-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 24(S)-hydroxyvitamin D₂(CAS DataBase Reference)
• NIST Chemistry Reference: 24(S)-hydroxyvitamin D₂(120707-37-1)
• EPA Substance Registry System: 24(S)-hydroxyvitamin D₂(120707-37-1)

Safety Data

• Hazardous Substances Data: 120707-37-1(Hazardous Substances Data)

Upstream product

• 89053-56-5 (2S-cis)-2-(1,1-dimethylethyl)-5-(1-methylethyl)-1,3-dioxolan-4-one 
• 58050-56-9 C₂₈H₄₄O₂ 
• 170081-45-5 3(S)-<(tert-butyldimethylsilyl)oxy>-20(S)-(iodomethyl)-9,10-secopregna-5(E),7(E),10(19)-triene 
• 344798-32-9 3(S)-<(tert-butyldimethylsilyl)oxy>-20(S)-(iodomethyl)-9,10-secopregna-5(Z),7(E),10(19)-triene SO2 adduct 
• 17407-55-5 (S)-2-Hydroxy-3-methylbutanoic acid 
• 344798-31-8 3(S)-<(tert-butyldimethylsilyl)oxy>-20(S)-(hydroxymethyl)-9,10-secopregna-5(Z),7(E),10(19)-triene SO2 adduct 
• 866453-60-3 3(S)-tert-butyldimethylsilyloxy-20(S)-formyl-9,10-secoprega-5,7(E),10⁽¹⁹⁾-triene 
• 87680-65-7 (S)-3-[(1R,3aS,7aR)-7a-Methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ⁶-benzo[c]thiophen-5-ol 
• 170081-43-3 SO2-adduct of 3(S)-<(tert-butyldimethylsilyl)oxy>-9,10-secoergosta-5,7(E),10(19),22(E)-tetraene 
• 50-14-6 Calciferol 
• 72-18-4 L-valine 
• 78640-99-0 (S)-(+)-2-hydroxy-2,3-dimethylbutanoic acid 

Relevant articles and documents

A stereospecific synthesis of 24(S)-hydroxyvitamin D2, a prodrug for 1α,24(S)-dihydroxyvitamin D2

This contribution describes the first stereospecific synthesis of 24(S)-hydroxyvitamin D2 (1), a metabolite of vitamin D2. This metabolite acts as a prodrug for 1α,24(S)-dihydroxyvitamin D2 (2), which is under development for treatment of various diseases characterized by cellular hyperproliferation. The key step of the synthesis involves the Wittig-Horner olefination of (S)-2,3-dimethyl-2-triethysilyloxybutyraldehyde (17) and a vitamin D2 phosphine oxide derivative (22). The synthesis of the requisite aldehyde started with the commercially available L-(+)-valine and was completed in seven steps. The vitamin D2 phosphine oxide derivative was synthesized in seven steps starting from vitamin D2.

Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2

A method of inhibiting the hyperproliferation of malignant or neoplastic cells, comprising treating the cells with an antiproliferative amount of 1α,24(S)-dihydroxyvitamin D2. The method also includes the co-administration of cyotoxic angents with the 1α,24(S)-dihydroxyvitamin D2.

24-hydroxyvitamin D, analogs and uses thereof

The invention provides 24-hydroxyvitamin D compounds and methods for their use in the treatment and prophylaxis of hyperparathyroidism and hyperproliferative diseases, and in the modulation of the immune and inflammatory responses as well as the treatment