170081-43-3Relevant articles and documents
Site-selective modification of vitamin D analogue (Deltanoid) through a resin-based version of organoselenium 2,3-sigmatropic rearrangement
Xu, Wei-Ming,He, Jun,Yu, Min-Qiang,Shen, Guo-Xiang
, p. 4431 - 4433 (2010)
Figure Presented. A site-selective modification of a vitamin D analogue (Deltanoid) through a two-step 2,3-sigmatropic rearrangement of organoselenium resin to prepare the key intermediate of calcipotriol has been developed. The polystyrene-supported sele
A calcitriol synthesis of intermediates method
-
, (2019/06/13)
The invention discloses a calcitriol intermediate compound preparation method, which belongs to the drug synthesis and organic compound synthesis technology field. The invention wide sources of raw materials are easy, simple and safe operation, environmen
A stereospecific synthesis of 24(S)-hydroxyvitamin D2, a prodrug for 1α,24(S)-dihydroxyvitamin D2
Coutts, Lisa D.,Geiss, William B.,Gregg, Brian T.,Helle, Mark A.,King, Chi-Hsin R.,Itov, Zinovy,Mateo, Mary E.,Meckler, Harold,Zettler, Mark W.,Knutson, Joyce C.
, p. 246 - 255 (2013/09/06)
This contribution describes the first stereospecific synthesis of 24(S)-hydroxyvitamin D2 (1), a metabolite of vitamin D2. This metabolite acts as a prodrug for 1α,24(S)-dihydroxyvitamin D2 (2), which is under development for treatment of various diseases characterized by cellular hyperproliferation. The key step of the synthesis involves the Wittig-Horner olefination of (S)-2,3-dimethyl-2-triethysilyloxybutyraldehyde (17) and a vitamin D2 phosphine oxide derivative (22). The synthesis of the requisite aldehyde started with the commercially available L-(+)-valine and was completed in seven steps. The vitamin D2 phosphine oxide derivative was synthesized in seven steps starting from vitamin D2.