866558-27-2Relevant academic research and scientific papers
Synthesis of trisubstituted furans via Ag-catalyzed cascade heterocyclization of 2-(1-alkynyl)-2-alken-1-ones with aryl-amines
He, Ting,Chi, Yaling,Chen, Yuantao
, p. 691 - 696 (2018)
Abstract: A silver(I)-catalyzed cascade heterocyclization of 2-(1-alkynyl)-2-alken-1-ones with aryl-amines is described to synthesize trisubstituted furans in moderate to good yields. Tertiary amine is also efficient in this reaction. This transformation
Modular access to 1,2-allenyl ketones based on a photoredox-catalysed radical-polar crossover process
Du, Chan,Fang, Jianghua,Fang, Yewen,Lei, Wan,Li, Yan,Liu, Yongjun
, p. 8502 - 8506 (2021/10/20)
Herein, a new protocol dealing with the preparation of 1,2-allenyl ketones has been successfully developedviathe reactions of enynes with radicals enabled by dual photoredox/copper catalysis. Based on the results of a deuteration experiment and the competition reaction between cyclopropanation and allenation, the mechanism based on a photoredox-neutral-catalysed radical-polar crossover process has been proposed. Synthetic applications of allenes have also been demonstrated.
Organocatalytic Formation of Chiral Trisubstituted Allenes and Chiral Furan Derivatives
Poulsen, Pernille H.,Li, Yang,Lauridsen, Vibeke H.,J?rgensen, Danny K. B.,Palazzo, Teresa A.,Meazza, Marta,J?rgensen, Karl Anker
supporting information, p. 10661 - 10665 (2018/07/30)
A novel reaction that provides chiral allenes by amino catalytic activation of either aldehydes or α,β-unsaturated aldehydes for reaction with alkynyl-substituted enones is presented. The reaction forms a variety of trisubstituted allenes in high yields a
Catalytic Asymmetric Epoxidation of Electron-Deficient Enynes Promoted by Chiral N,N′-Dioxide-Scandium(III) Complex
Zhang, Hang,Yao, Qian,Lin, Lili,Xu, Chaoran,Liu, Xiaohua,Feng, Xiaoming
, p. 3454 - 3459 (2017/10/09)
An asymmetric epoxidation of electron-deficient enynes with environmentally benign aqueous hydrogen peroxide as oxidant has been accomplished by developing a chiral N,N′-dioxide-Scandium(III) complex catalytic system. In the presence of 0.5–2 mol% catalys
Gold-Catalyzed Concomitant [3 + 3] Cycloaddition/Cascade Heterocyclization of Enynones/Enynals with Azides Leading to Furanotriazines
Siva Kumari, A. Leela,Kumara Swamy
, p. 1425 - 1433 (2016/03/01)
[Au]-catalyzed [3 + 3] cycloaddition reaction of enynones/enynals with azides, which allows the efficient regioselective synthesis of highly fused furo[3,4-d][1,2,3]triazines in good-to-excellent yields under mild conditions, has been developed. The synth
Chemoselective C-C bond cleavage of epoxide motifs: Gold(I)-catalyzed diastereoselective [4+3] cycloadditions of 1-(1-Alkynyl)oxiranyl ketones and nitrones
Wang, Tao,Zhang, Junliang
, p. 86 - 90 (2011/03/20)
Cutting carbon! A novel facile strategy for the C-C bond cleavage of oxiranyl ketones has been developed. Carbophilic gold(I) activation of the alkyne side chain mediates a heterocyclization and subsequent C-C bond cleavage (see scheme).
Synthesis of highly substituted furans by the electrophile-induced coupling of 2-(1-alkynyl)-2-alken-1-ones and nucleophiles
Yao, Tuanli,Zhang, Xiaoxia,Larock, Richard C.
, p. 7679 - 7685 (2007/10/03)
The coupling of 2-(1-alkynyl)-2-alken-1-ones with nucleophiles, either catalyzed by AuCl3 or induced by an electrophile, provides highly substituted furans in good to excellent yields under very mild reaction conditions. Various nucleophiles, i
