86671-60-5

Upstream product

• 20939-15-5 3-methyl-4-amino-5-mercapto-1,2,4-triazole 
• 1985-12-2 4-Bromophenyl isothiocyanate 
• 75105-07-6 N_⁽¹⁾-(4-bromophenyl)-N,N-dimethylthiourea 
• 106-40-1 4-bromo-aniline 
• 86671-66-1 1-(4-Bromo-phenyl)-3-(3-mercapto-5-methyl-[1,2,4]triazol-4-yl)-thiourea 

Relevant academic research and scientific papers

Use of tetramethylthiuram disulfide in synthesis of nitrogen-containing heterocyclic compounds

We have developed a method for synthesis of aryl isothiocyanates by means of thiocarbamoylation of aromatic amines by tetramethylthiuram disulfide followed by degradation of the intermediate N(1)-aryl-N,N- dimethylthiourea by concentrated HCl. We have shown that thiocarbamoylation of 4-amino-5-ethyl-4H-1,2,4-triazole-3-thiol occurs at the 2 position of the triazole ring, while thiocarbamoylation of 4-amino-3-methyl-6-phenyl-4,5- dihydro-1,2,4-triazin-5-one leads to the dihetaryl-substituted thiourea. We consider the possibility of using N(1)-aryl-N,N-dimethylthioureas as analogs of isothiocyanates in reactions with N-nucleophiles. 2005 Springer Science+Business Media, Inc.