75105-07-6

Upstream product

• 124-40-3 dimethyl amine 
• 1985-12-2 4-Bromophenyl isothiocyanate 
• 6906-32-7 N,N,2-Trimethyl-1-propen-1-amin 
• 63407-92-1 N,N,2-Trimethyl-1-buten-1-amin 
• 75-04-7 ethylamine 
• 137-26-8 Thiram 
• 106-40-1 4-bromo-aniline 
• 33842-02-3 dichloromethylenedimethyliminium chloride 

Downstream Products

• 86671-60-5 6-(4-bromophenylamino)-3-methyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1329429-83-5 3-(4-bromophenyl)-1,1-dimethyl-2-phenyl-isothiourea 
• 1329429-81-3 N'-(4-bromophenyl)-N,N-dimethyl-2-phenylsulfanyl-benzamidine 
• 1985-12-2 4-Bromophenyl isothiocyanate 
• 75104-96-0 6-bromo-N,N-dimethylbenzo[d]thiazol-2-amine 

Relevant academic research and scientific papers

Facile one-pot synthesis of thio and selenourea derivatives: A new class of potent urease inhibitors

A facile, one-pot synthesis of thio and selenourea derivatives from amines using tetrathiomolybdate 1 and tetraselenotungstate 2 as sulfur and selenium transfer reagents, respectively, is reported. The compounds were tested for their activity as urease in

Method for preparing aryl isothiourea

The invention discloses a method for preparing aryl isothiourea, wherein hydride is suspended in a solvent, and thiourea is sequentially added. O diiodo benzene followed by reaction to prepare aryl isothiosemicarbazone. The isothiourea structure is widely

Insertion of arynes into thioureas: A new amidine synthesis

Arynes, generated from trimethylsilyl phenyltriflate precursors, have been found to react with thioureas via a formal π-insertion into the C=S bond. The reaction contrasts with that of ureas, which proceeds via benzyne σ-insertion into the C-N bond, and r

Use of tetramethylthiuram disulfide in synthesis of nitrogen-containing heterocyclic compounds

We have developed a method for synthesis of aryl isothiocyanates by means of thiocarbamoylation of aromatic amines by tetramethylthiuram disulfide followed by degradation of the intermediate N(1)-aryl-N,N- dimethylthiourea by concentrated HCl. We have shown that thiocarbamoylation of 4-amino-5-ethyl-4H-1,2,4-triazole-3-thiol occurs at the 2 position of the triazole ring, while thiocarbamoylation of 4-amino-3-methyl-6-phenyl-4,5- dihydro-1,2,4-triazin-5-one leads to the dihetaryl-substituted thiourea. We consider the possibility of using N(1)-aryl-N,N-dimethylthioureas as analogs of isothiocyanates in reactions with N-nucleophiles. 2005 Springer Science+Business Media, Inc.

Quantitative solid-state reactions of amines with carbonyl compounds and isothiocyanates

A series of solid-state reactions is reported of gaseous or solid amines with aldehydes to give imines, with solid anhydrides to give diamides (therefrom imides) or amidic carboxylic salts or imides, with solid imides to give diamides, with solid lactones or carbonates to give functionalized carbamic esters, with polycarbonates to give degradative aminolysis, and with solid isothiocyanates to give thioureas. Diamides give imides by solid-state thermolysis or acid catalysis. Various double, two-step, 3-cascade, and sequential reactions are reported in the solid state without melting. The yields are quantitative in 53 reported reaction examples and no workup (except for washings in four cases) is required in the 100% yield reactions. Three initially solid-state reactions but with liquid product were not quantitative. An upscaling to the kg scale shows promise of the technique for large scale applications. Supermicroscopic analyses with AFM elucidate the solid-state mechanism by virtue of far-reaching anisotropic molecular movements in three-step processes. Gas-solid aminolyses of polycarbonates are also studied with AFM. The implications to sustainable chemistry are discussed. (C) 2000 Elsevier Science Ltd.

Cycloaddition Reactions of Heterocumulenes, XXVI. Cycloadducts from Aryl Isothiocyanates and 2,2-Disubstituted Enamines

Aryl isothiocyanates 1 react with enamines 2 to give two types of 2:1 cycloadducts.Below 50 deg C, 1a - g and 2 give rise to 6-imino-1,3-thiazine-2-thiones 5, the constitutions of which are proved by an X-ray analysis of 5c.Above 50 deg C or starting from 4-nitrophenyl isothiocyanate (1h), 2,4-dithiouracils 6 are formed. 1:1 cycloadducts of the reactants are detected spectroscopically; on workup, they hydrolyze to give 2-formylthiopropionanilides 9.