866821-33-2

Upstream product

• 26050-64-6 methyl 4-bromo-3,5-dimethoxybenzoate 
• 55703-81-6 4-isopropyl-3,5-dimethoxybenzoic acid 
• 866821-37-6 methyl 3-(4-isopropyl-3,5-dimethoxyphenyl)-3-oxopropanoate 
• 866821-31-0 methyl 3,5-dimethoxy-4-(prop-1-en-2-yl)benzoate 
• 344396-17-4 methyl 4-isopropyl-3,5-dimethoxybenzoate 
• 866821-32-1 4-isopropyl-3,5-dimethoxyacetophenone 
• 866821-38-7 2-(4-isopropyl-3,5-dimethoxy-benzoyl)-5-methyl-hex-5-enoic acid methyl ester 

Downstream Products

• 866821-34-3 5-[1-(4-isopropyl-3,5-dimethoxyphenyl)-5-methyl-5-hexenylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 866821-30-9 (+/-)-5-[1-(4-isopropyl-3,5-dimethoxyphenyl)-1,5-dimethyl-5-hexenyl]-2,2-dimethyl-1,3-dioxane-4,6-dione 

Relevant academic research and scientific papers

Total synthesis of (±)-Taiwaniaquinol B via a domino intramolecular Friedel-Crafts acylation/carbonyl α-tert-alkylation reaction

The first synthesis of taiwaniaquinol B, a 6-nor-5(6→7)abeoabietane-type diterpenoid exhibiting the uncommon fused 6-5-6 tricyclic carbon skeleton, was accomplished in 15 steps. A Lewis acid-promoted tandem intramolecular Friedel-Crafts/carbonyl α-tert-alkylation reaction was exploited as the core strategy for the synthesis of the sterically congested 1-indanone-containing tricyclic structure. This multiple carbon-carbon bond forming reaction exploits the unique reactivity of Meldrum's acid. The facile precursor synthesis makes this a useful methodology for the expedient modification and assembly of sterically congested 1-indanone-containing ring systems. Copyright