866865-78-3Relevant academic research and scientific papers
Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei
Abdelwahab, Nuha Z.,Urbaniak, Michael D.,Ferguson, Michael A.J.,Crossman, Arthur T.
scheme or table, p. 708 - 714 (2011/05/07)
A small zinc-binding group (ZBG) library of deoxy-2-C-branched- monosaccharides, for example, 1,5-anhydroglucitols, consisting of either monodentate ligand binding carboxylic acids or bidentate ligand binding hydroxamic acids, were prepared to assess the
Mapping the active site of the bacterial enzyme LpxC using novel carbohydrate-based hydroxamic acid inhibitors
Li, Xuechen,McClerren, Amanda L.,Raetz, Christian R. H.,Hindsgaul, Ole
, p. 583 - 609 (2007/10/03)
LpxC (UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase), an enzyme involved in the biosynthesis of lipid A, is crucial for the growth of Gram-negative bacteria. This enzyme has accordingly been identified as a potential target for the development of nove
