866885-85-0

Upstream product

• 1069-23-4 (3R,4R)-1,5-hexadiene-3,4-diol 
• 69-65-8 mannitol 
• 803684-08-4 acrylic acid (2R)-benzyloxy-(1R)-vinylbut-3-enyl ester 
• 66927-75-1 8-(trimethylsilyl)-1-octen-7-yn-3-ol 
• 628687-60-5 (E)-1,7-Diiodo-hept-1-ene 
• 628687-58-1 ethyl (trans)-10-(trimethylsilyl)dec-4-en-9-ynoate 
• 63478-76-2 1-hydroxy-6-heptyne 
• 866885-77-0 (5S)-3-(7-iodohept-6-enyl)-5-methyl-3-(phenylsulfanyl)tetrahydrofuran-2-one 
• 866885-74-7 5R-(1R-hydroxy-6-trimethylsilylhex-5-ynyl)dihydrofuran-2-one 
• 866885-76-9 5R-(1R-hydroxyhex-5-ynyl)dihydrofuran-2-one 
• 112790-78-0 (3R,4R)-4-benzyloxy-hexa-1,5-dien-3-ol 
• 866885-81-6 (5S)-3-[(R)-13-hydroxy-13-((R)-5-oxotetrahydrofuran-2-yl)tridec-6-en-8-ynyl]-5-methyl-3-(phenylsulfanyl)dihydrofuran-2-one 

Relevant academic research and scientific papers

Convergent total synthesis of squamostolide

A convergent total synthesis of the Annonaceous acetogenin squamostolide, in a longest linear sequence of nine steps from d-mannitol, is reported. Central to the efficiency of the synthesis is a highly selective tandem ring-closing/cross metathesis step in which lactone formation and fragment coupling are accomplished.

Design, syntheses, and biological evaluations of squamostolide and its related analogs

Squamostolide and its related analogs were designed and synthesized for biological evaluation. All these compounds were tested for growth inhibition activities against human tumor cell lines, in which one of the compounds showed the most potent cytotoxici