866996-44-3Relevant articles and documents
Preparation method of benzyl aryl ether and application of benzyl aryl ether in synthesis
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Paragraph 0139-0141, (2021/09/01)
and, 6-dihydrodibenzo [11 - b] oxazepine e -11 - ketone compounds are synthesized through a one-step reaction of benzaldehyde compounds and phenolic compounds through one-step reaction. The benzyl aryl ether and 6 and 11 -dihydrodibenzo [b, e] oxazepine -11 - ketone compound respectively have a chemical structure formula shown in a formula I and II. The invention discloses a synthesis method of the compound. Benzaldehyde compound After completion of the reaction, I, 6-dihydrodibenzo [11 - b] oxazepine e ketone compound -11 - can be synthesized through an oxidation or hydrolysis step and a ring closing step after the reaction is complete II.
Synthetic method of doxepin hydrochloride adopting o-halogen methyl benzoate as raw material
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, (2016/10/07)
The invention discloses a synthetic method of doxepin hydrochloride adopting o-halogen methyl benzoate as a raw material. The synthetic method comprises: taking the o-methyl benzoate wide in source as a starting raw material, and sequentially carrying out benzyl halogenations, substitution, hydrolysis, cyclization, nucleophilic addition, nucleophilic substitution and neutralization to obtain salazosulfapyridine. In the nucleophilic substitution step of step 7, an organic lithium compound is dissolved in an ether solvent, so that the organic lithium compound and dimethylamine react to form an ammonium lithium salt (see the description), then the ammonium lithium salt is subjected to alkylation reaction with a halogen compound, the yield of the tertiary ammonium is increased, and the yield and purity of the final doxepin hydrochloride can be guaranteed.
