86700-21-2Relevant academic research and scientific papers
Simple, multicomponent, ecofriendly, microwave-mediated route for the synthesis of antimicrobial 2-amino-6-aryl-4-(3 h)-pyrimidinones
Da Silva, Ivangela E. A.,Braga, Vanildo M. L.,Melo, Mychely S.,Correia, Maria Tereza Dos S.,Dos Anjos, Janaina V.
supporting information, p. 374 - 380 (2014/01/06)
In this work, we describe a multicomponent microwave-mediated synthesis of 10 2-amino-6-aryl-4-oxo-1,6-dihydro-pyrimidine-5-carbonitriles in good chemical yields (44-67%), four of them not related in earlier literature. All pyrimidinones synthesized herein had their antimicrobial activity evaluated against the following microorganisms: Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. Two of the synthesized substances displayed good antimicrobial activity against P. aeruginosa and S. aureus, two bacteria responsible for nosocomial infections. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]
A novel and efficient one-pot synthesis of 2-aminopyrimidinones and their self-assembly
Bararjanian, Morteza,Balalaie, Saeed,Rominger, Frank,Barouti, Sanaz
experimental part, p. 777 - 784 (2010/06/17)
A three-component reaction of benzaldehyde derivatives, methyl cyanoacetate, and guanidinium carbonate affords 2-amino-4-aryl-1,6-dihydro-6- oxopyrimidine-5-carbonitriles and the four-component reaction of benzaldehyde derivatives, methyl cyanoacetate, and guanidinium hydrochloride in the presence of piperidine leads to piperidinium salts of pyrimidinones. X-ray crystallography data confirm self-assembly and H-bonding in these compounds.
