86733-61-1Relevant articles and documents
Synthetic studies on antibiotic validamycins. Part 13. Total synthesis of (+)-validamycins A and E, and related compounds
Miyamoto, Yasunobu,Ogawa, Seiichiro
, p. 1013 - 1018 (2007/10/02)
(+)-Validoxylamine A (1) has been completely synthesized by deoxygenation of the validoxylamine B derivative (6) through formation of the aziridine, nucleophilic displacement with toluenethiol, reduction with Raney nickel, and deprotection. The validoxylamine A derivative (10) obtained was convertible, by glycosylation followed by deprotection, into validamycins A (2), E (3), and their analogues, which constitutes a total synthesis thereof.
A FORMAL TOTAL SYNTHESIS OF VALIDAMYCIN A
Ogawa, Seiichiro,Ogawa, Takao,Nose, Taisuke,Toyokuni, Tatsushi,Iwasawa, Yoshikazu,et al.
, p. 921 - 922 (2007/10/02)
Validamycin A has been prepared by a glycosidation of the partly blocked validoxylamine A, followed by deprotection.Since a racemic form of validoxylamine A has been totally synthesized, the synthesis of validamycin A is achieved by the present study.