86752-05-8Relevant academic research and scientific papers
Generation and Synthetic Utility of Dianions Derived from Thiophencarboxylic Acids
Knight, David W.,Nott, Andrew P.
, p. 791 - 794 (2007/10/02)
Thiophen-2- and -3-carboxylic acid are rapidly and regioselectively metallated by lithium di-isopropylamide in tetrahydrofuran at -78 deg C.The resulting dianionic species react with a range of electrophiles to give the expected thiophencarboxylic acid homologues in good-to-excellent yields.
