77756-31-1

Upstream product

• 88-13-1 3-Thiophene carboxylic acid 
• 100-52-7 benzaldehyde 

Downstream Products

• 86752-05-8 methyl 2-(α-hydroxybenzyl)thiophen-3-carboxylate 
• 80727-84-0 7-phenylthieno[2,3-d]pyridazin-4(5H)-one 
• 1309195-34-3 5-amino-7-phenylthieno[2,3-d]pyridazin-4(5H)-one 
• 30011-75-7 2-(phenylcarbonyl)thiophene-3-carboxylic acid 
• 950911-21-4 6-phenyl-6H-thieno[2,3-c]furan-4-one 

Relevant academic research and scientific papers

Development of novel pyridazinone-based adenosine receptor ligands

With the aim of finding new adenosine receptor (AR) ligands, a preliminary investigation focusing on the thieno[2,3-d]pyridazin-5(4H)-one scaffold was undertaken. The synthesized compounds 1–11 were evaluated for their binding at hA1, hA2A

HETEROARYL DIHYDROINDOLONES AS KINASE INHIBITORS

The present invention provides a compound represented by the formula: wherein the variables R1, b, R6, Y, Z, X, R and a are defined in the specification. Said compound may be used in a method for treating diseases related to unregula

Generation and Synthetic Utility of Dianions Derived from Thiophencarboxylic Acids

Thiophen-2- and -3-carboxylic acid are rapidly and regioselectively metallated by lithium di-isopropylamide in tetrahydrofuran at -78 deg C.The resulting dianionic species react with a range of electrophiles to give the expected thiophencarboxylic acid homologues in good-to-excellent yields.

Formation and reactivity of dianions derived from 2- and 3-thiophencarboxylic acids

Dianions (3) and (6) can be generated in high yield from the corresponding thiophencarboxylic acids with lithium diisopropylamide and react with a number of representative electrophiles to give fair to good yields of 5-substituted-thiophen-2-carboxylic acids and 2-substituted thiophen-3-carboxylic acids respectively.