86768-17-4

Upstream product

• 86768-23-2 2,4-dioxo-3,4-diphenyl-butyric acid ethyl ester 
• 100-63-0 phenylhydrazine 
• 451-40-1 phenyl benzyl ketone 
• 59-88-1 phenylhydrazine hydrochloride 
• 4755-77-5 Ethyl oxalyl chloride 

Downstream Products

• 86768-19-6 (1,4,5-Triphenyl-3-pyrazolyl)-methanol 
• 86768-20-9 3-Brommethyl-1,4,5-triphenyl-pyrazol 
• 86768-21-0 1,4,5-Triphenyl-pyrazol-3-acetonitril 
• 86768-22-1 1,4,5-Triphenyl-pyrazol-3-essigsaeure 
• 854699-33-5 1,4,5-triphenyl-1H-pyrazole-3-carbonyl chloride 
• 854699-69-7 1,4,5-triphenyl-1H-pyrazole-3-carboxylic acid 

Relevant academic research and scientific papers

A one-pot approach to ethyl 1,4,5-triaryl-1H-pyrazole-3-carboxylates via an improved claisen condensation-knorr reaction sequence

A one-pot approach to ethyl 1,4,5-triaryl-1H-pyrazole-3-carboxylates has been developed in moderate to high yields. The tert-BuOLi-mediated Claisen condensation of 1,2-diarylethanones and ethyl oxalyl chloride efficiently provided the enolized lithium salts of ethyl 2,4-dioxo-3,4-diarylbutanoates, which in situ reacted with arylhydrazine hydrochlorides via a hydrochloric acid-promoted Knorr reaction to produce the exquisite triarylpyrazole-3- carboxylates. The procedure promises a convenient access to this highly crowded framework for drug discovery. Copyright