86768-18-5Relevant academic research and scientific papers
One-Pot Synthesis of Highly Substituted 1H-Pyrazole-5-carboxylates from 4-Aryl-2,4-diketoesters and Arylhydrazines
Zhai, Jiao-Jiao,Gu, Chun-Hui,Guo, Ying,Liao, Dao-Hua,Zhu, Dun-Ru,Ji, Ya-Fei
, p. 840 - 848 (2016/05/19)
A one-pot synthesis of highly substituted 1H-pyrazole-5-carboxylates 1 has been developed starting from easily available 4-aryl-2,4-diketoesters 2 and arylhydrazine hydrochlorides 3. More active 2-carbonyl group of 2 was blocked with methoxyamine hydrochloride to give 2-methoxy imine intermediates, which were then subjected to condensation cyclization with 3 in situ to provide the desired products 1. In addition, the geometrical configuration of 1aa was unambiguously confirmed by single crystal X-ray crystallography.
A facile approach to polysubstituted pyrazoles from hydrazonyl chlorides and vinyl azides
Zou, Hongbin,Zhu, Huajian,Shao, Jiaan,Wu, Jianwei,Chen, Wenteng,Giulianotti, Marc A.,Yu, Yongping
supporting information; experimental part, p. 4887 - 4891 (2011/07/29)
A novel and facile approach to polysubstituted pyrazoles from readily synthesized hydrazonyl chlorides and vinyl azides was developed. The reaction was regiospecific and proceeded under mild conditions in the presence of base.
Synthesis of pyrazoles from 2-azidoacrylates and hydrazonyl chlorides
Li, Yao,Hong, Deng,Lu, Ping,Wang, Yanguang
supporting information; experimental part, p. 4161 - 4163 (2011/09/19)
A regioselective synthesis of 1,3,4,5-tetrasubstituted pyrazoles is established between 2-azidoacrylates and hydrazonyl chlorides in the presence of triethylamine. The yields are moderate (43-73%) and a possible mechanism for this transformation is postul
PROCESS FOR THE SYNTHESIS OF SUBSTITUTED PYRAZOLES
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Page/Page column 12, (2010/05/13)
A process for the preparation of 4,5-di- and 2,4,5-trisubstituted pyrazole 3-carboxylates from 3-acyloxirane-2-carboxylates and hydrazine compounds.
