86770-76-5

Usage

Uses

Given the limited information available on 1-Phenyl-2,5,8,11-tetraoxatridecan-13-amine, its uses are not clearly defined. However, based on its chemical structure, it may have potential applications in the following areas:
Used in Organic Chemistry:
1-Phenyl-2,5,8,11-tetraoxatridecan-13-amine is used as a reactant for [specific reactions or synthesis processes] in organic chemistry due to its unique structure that allows for [certain types of chemical interactions or reactions].
Used in Pharmaceutical Development:
1-Phenyl-2,5,8,11-tetraoxatridecan-13-amine is used as a precursor or intermediate in the development of pharmaceutical compounds for [specific therapeutic areas or drug classes], leveraging its chemical properties to enhance [desired pharmacological effects or improve drug delivery].
Used in Material Science:
1-Phenyl-2,5,8,11-tetraoxatridecan-13-amine is used as a component in the synthesis of new materials for [specific applications such as coatings, adhesives, or polymers], taking advantage of its structural features to impart [certain properties like adhesion, flexibility, or durability].

Upstream product

• 86770-71-0 ((2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)methyl)benzene 
• 477781-69-4 1-phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate 
• 112-60-7 Tetraethylene glycol 
• 100-39-0 benzyl bromide 
• 89346-82-7 2-<2-<2-<2-(benzyloxy)ethoxy>ethoxy>ethoxy>ethyl 4-methylbenzenesulfonate 
• 86259-87-2 1-phenyl-2,5,8,11-tetraoxatridecan-13-ol 

Relevant academic research and scientific papers

A MedChem toolbox for cereblon-directed PROTACs

A modular chemistry toolbox was developed for cereblon-directed PROTACs. A variety of linkers was attached to a CRBN ligand via the 4-amino position of pomalidomide. We used linkers of different constitution to modulate physicochemical properties. We equipped one terminus of the linker with a set of functional groups, e.g. protected amines, protected carboxylic acids, alkynes, chloroalkanes, and protected alcohols, all of which are considered to be attractive for PROTAC design. We also highlight different opportunities for the expansion of the medicinal chemists' PROTAC toolbox towards heterobifunctional molecules, e.g. with biotin, fluorescent, hydrophobic and peptide tags.

HIGHLY FLUORINATED OILS AND SURFACTANTS AND METHODS OF MAKING AND USING SAME

Disclosed are compounds comprising the structure (I): In one aspect, the compounds exhibit maximum symmetric branching. Also disclosed are bilayers, micelles, coatings, and nanoparticles comprising the disclosed compounds. Also disclosed are processes for

Lack of effect of the length of oligoglycine- and oligo(ethylene glycol)-derived para-substituents on the affinity of benzenesulfonamides for carbonic anhydrase II in solution

Using 1H NMR spectroscopy, values of T2 have been determined for the methylene protons of the oligoglycine moieties of para-substituted benzenesulfonamides having structures H2NO2SC6H4CO(Gly)(n)OH (n = 1-6) bound at the active site of bovine carbonic anhydrase II (CA, EC 4.2.1.1). These values have been correlated with measurements of dissociation constants of these complexes, in order to infer motion of these ligands when bound to the enzyme. Motion of glycines 1-3 (those closest to the aryl ring) is hindered by their proximity to the protein; motion of glycines 4-6 is relatively unhindered. Despite the restriction to motion inferred for glycines 1-3, the values of K(d) for the six compounds (n = 1-6, 1-6) are indistinguishable within experimental uncertainty (± 20%): K(d) in μM (n) 0.30 (1); 0.26 (2); 0.33 (3); 0.37 (4); 0.37 (5); 0.34 (6). There is, therefore, an unexpected compensation of the loss in conformational entropy on binding by another contributor to the free energy.

REDUCTION D'AZIDES EN AMINES PAR LE FORMIATE D'AMMONIUM PAR "TRANSFERT D'HYDROGENE CATALYSE" (CTH)

The azides are reduced to amines in very good yields by "Catalytic Transfer Hydrogenation" (CTH) using ammonium formate.