86770-77-6 Usage
Uses
Used in Pharmaceutical Industry:
Benzyl-PEG5-Amine is used as a protecting group for alcohol moieties in the synthesis of pharmaceutical compounds. Its benzyl group can be easily removed via hydrogenolysis, facilitating the production of the desired drug molecules.
Used in Bioconjugation:
Benzyl-PEG5-Amine is used as a linker in bioconjugation processes for attaching biologically active molecules to other entities. The free terminal amine allows for the formation of stable covalent bonds with carboxylic acids, activated NHS esters, and other carbonyl compounds, enabling the creation of conjugates with improved stability and solubility.
Used in Drug Delivery Systems:
Benzyl-PEG5-Amine is used as a component in the design of drug delivery systems. The hydrophilic PEG linkers improve the water solubility of drug molecules, potentially enhancing their bioavailability and therapeutic efficacy. Additionally, the benzyl protecting group can be utilized to control the release of the drug by removing it under specific conditions.
Used in Chemical Synthesis:
Benzyl-PEG5-Amine is used as an intermediate in the synthesis of various chemical compounds. Its versatility in reacting with different functional groups and the ease of removal of the benzyl group make it a valuable building block in organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 86770-77-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,7,7 and 0 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 86770-77:
(7*8)+(6*6)+(5*7)+(4*7)+(3*0)+(2*7)+(1*7)=176
176 % 10 = 6
So 86770-77-6 is a valid CAS Registry Number.
86770-77-6Relevant academic research and scientific papers
Lack of effect of the length of oligoglycine- and oligo(ethylene glycol)-derived para-substituents on the affinity of benzenesulfonamides for carbonic anhydrase II in solution
Jain, Ahamindra,Huang, Shaw G.,Whitesides, George M.
, p. 5057 - 5062 (2007/10/02)
Using 1H NMR spectroscopy, values of T2 have been determined for the methylene protons of the oligoglycine moieties of para-substituted benzenesulfonamides having structures H2NO2SC6H4CO(Gly)(n)OH (n = 1-6) bound at the active site of bovine carbonic anhydrase II (CA, EC 4.2.1.1). These values have been correlated with measurements of dissociation constants of these complexes, in order to infer motion of these ligands when bound to the enzyme. Motion of glycines 1-3 (those closest to the aryl ring) is hindered by their proximity to the protein; motion of glycines 4-6 is relatively unhindered. Despite the restriction to motion inferred for glycines 1-3, the values of K(d) for the six compounds (n = 1-6, 1-6) are indistinguishable within experimental uncertainty (± 20%): K(d) in μM (n) 0.30 (1); 0.26 (2); 0.33 (3); 0.37 (4); 0.37 (5); 0.34 (6). There is, therefore, an unexpected compensation of the loss in conformational entropy on binding by another contributor to the free energy.
REDUCTION D'AZIDES EN AMINES PAR LE FORMIATE D'AMMONIUM PAR "TRANSFERT D'HYDROGENE CATALYSE" (CTH)
Gartiser, T.,Selve, C.,Delpuech, J.-J.
, p. 1609 - 1610 (2007/10/02)
The azides are reduced to amines in very good yields by "Catalytic Transfer Hydrogenation" (CTH) using ammonium formate.
