86771-01-9

Basic information

• Product Name: Benzeneacetonitrile, a-(1H-pyrrol-2-ylmethylene)-, (Z)-
• CAS NO: 86771-01-9
• Molecular Formula: C13H10N2
• Molecular Weight: 194.236
• Mol File: 86771-01-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzeneacetonitrile, a-(1H-pyrrol-2-ylmethylene)-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, a-(1H-pyrrol-2-ylmethylene)-, (Z)-(86771-01-9)
• EPA Substance Registry System: Benzeneacetonitrile, a-(1H-pyrrol-2-ylmethylene)-, (Z)-(86771-01-9)

Safety Data

• Hazardous Substances Data: 86771-01-9(Hazardous Substances Data)

Upstream product

• 5427-82-7 1H-pyrrole-2-carbonyl chloride 
• 75-05-8 acetonitrile 
• 164594-13-2 Phenyl[2-(trimethylsilyl)phenyl]iodonium trifluoromethanesulfonate 
• 1003-29-8 2-pyrrole aldehyde 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 1295627-05-2 C₁₃H₁₆N₂ 
• 1295627-12-1 2-phenyl-3-(1H-pyrrol-2-yl)propanenitrile 

Relevant articles and documents

The influence of ionic liquids on the Knoevenagel condensation of 1H-pyrrole-2-carbaldehyde with phenyl acetonitriles-cytotoxic 3-substituted-(1H-pyrrol-2-yl)acrylonitriles

The Knoevenagel condensation of a series of substituted phenyl acetonitriles with 1H-pyrrole-2-carbaldehyde was examined in seven 1-butyl-3-methylimidazolium based ionic liquids and three protic ionic liquids. Of these [BMIM][Br] and [BMIM][OH], with cata

Norcantharidin analogues with nematocidal activity in Haemonchus contortus

With the major problems with resistance in parasitic nematodes of livestock to anthelmintic drugs, there is an urgent need to develop new nematocides. In the present study, we employed a targeted approach for the design of a series of norcantharidin analogues (n = 54) for activity testing against the barber's pole worm (Haemonchus contortus) of small ruminants in a larval development assay (LDA) and also for toxicity testing on nine distinct human cell lines. Although none of the 54 analogues synthesized were toxic to any of these cell lines, three of them (N-octyl-7-oxabicyclo(2.2.1)heptane-2,3-dicarboximide (B2), N-decyl-7-oxabicyclo(2.2.1)heptane-2,3-dicarboximide (B3) and 4-[(4-methyl)-3-ethyl-2-methyl-5-phenylfuran-10-oxa-4-azatricyclo[5.2.1] decane-3,5-dione (B21) reproducibly displayed 99-100% lethality to H. contortus in LDA, with LD50s of 25-40 μM. The high 'hit rate' (5.6%) indicates that the approach taken here has advantages over conventional drug screening methods. A major advantage of norcantharidin analogues over some other currently available anthelmintics is that they can be produced in one to two steps in large amounts at low cost and high purity, and do not require any additional steps for the isolation of the active isomer. This positions them well for commercial development.

CONTROL OF PARASITES IN ANIMALS BY THE USE OF PARASITICIDAL 2-PHENYL-3-(1H-PYRROL-2-YL) ACRYLONITRILE DERIVATIVES

2-Phenyl-3-(1H-pyrrol-2-yl)acrylonitrile compounds useful for controlling parasites in animals and methods of treatment of parasite infestation in animals using the compounds are disclosed.