86781-35-3Relevant academic research and scientific papers
Assembly of N,N-disubstituted-N′-arylureas via a copper-catalyzed one-pot three-component reaction of aryl bromides, potassium cyanate, and secondary amines
Yin, Hongfei,Chen, Bing,Zhang, Xiaojing,Yang, Xinye,Zhang, Yihua,Jiang, Yongwen,Ma, Dawei
, p. 5326 - 5330 (2013/07/05)
A three-component reaction of aryl bromides, potassium cyanate, and secondary amines takes place at 110 C in MeCN under the catalysis of Cu 2O and 2-(2,6-dimethylphenylamino)-2-oxoacetic acid potassium salt, giving N,N-disubstituted-N′-arylurea
Practical synthesis of urea derivatives
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, (2008/06/13)
STR1 A very mild and efficient approach for the synthesis of ureas is described. Phenyl carbamates were used as intermediates for the preparation of N,N'- substituted ureas. The carbamates were treated with an approximate stoichiometric amount of amine in dimethyl sulfoxide at ambient temperature, generating the ureas in high yield. The reaction was simple, safe, fast, inexpensive, and amenable to large scale production of the product.
A practical synthesis of ureas from phenyl carbamates
Thavonekham, Bounkham
, p. 1189 - 1194 (2007/10/03)
Using DMSO as solvent, a mild and efficient procedure for the synthesis of unsymmetrical N,N'-disubstituted ureas from phenyl carbamates is described. The carbamates are treated with a stoichiometric amount of amine at ambient temperature, generating the
Potential Antiatherosclerotic Agents. 6. Hypocholesterolemic Trisubstituted Urea Analogues
DeVries, Vern G.,Bloom, Jonathan D.,Dutia, Minu D.,Katocs, Andrew S.,Largis, Elwood E.
, p. 2318 - 2325 (2007/10/02)
The discovery that a series of N,N-dialkyl-N'-arylureas were inhibitors of the ACAT enzyme has led to a structure-activity study involving the systematic modification of three sites of the urea backbone.This study culminated in the selection of N'-(2,4-dimethylphenyl)-N-benzyl-N-n-butylurea (115) for more extensive biological evaluation.ACAT inhibitors are seen as potentially beneficial agents against hypercholesterolemia and atherosclerosis.
