86788-63-8

Upstream product

• 699-83-2 2,6-dihydroxylacetophenone 
• 100-39-0 benzyl bromide 
• 4047-24-9 1-[2-(benzyloxy)-6-hydroxyphenyl]ethanone 
• 6515-21-5 4-methoxymethoxy-benzaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 86788-70-7 (+/-)-2,3-trans-5',4-dimethoxyflavan-3-ol 
• 86788-65-0 (2R^*,3R^*)-5,4'-dihydroxyflavanonol 
• 21187-77-9 (+/-)-2,3-trans-3,4-trans-3,4,5,4'-tetrahydroxyflavan 
• 86788-66-1 (2S,3R,4S)-5-Methoxy-2-(4-methoxy-phenyl)-chroman-3,4-diol 
• 86788-69-4 [(2S,3S,4S)-3-Hydroxy-5-methoxy-2-(4-methoxy-phenyl)-chroman-4-ylsulfanyl]-acetic acid methyl ester 
• 86788-67-2 Acetic acid (2S,3S,4S)-3-acetoxy-5-methoxy-2-(4-methoxy-phenyl)-chroman-4-yl ester 
• 86788-68-3 (+/-)-fistacacidin tetraacetate 
• 86788-64-9 (2R^*,3R^*)-5-benzyloxy-4'-hydroxyflavanonol 

Relevant academic research and scientific papers

Anti-proliferative effect of chalcone derivatives through inactivation of NF-κB in human cancer cells

To investigate the anti-proliferative effect of NF-κB inhibitor, a series of analogs of (E)-1-(2-hydroxy-6-(isopentyloxy)phenyl)-3-(4- hydroxyphenyl)prop-2-en-1-one (5a) were prepared and evaluated for their NF-κB inhibition and anti-proliferative activity against various human cancer cell lines. Compounds (E)-1-(2-(3,3-dimethylbutoxy)-6-hydroxyphenyl)-3- (4-hydroxyphenyl)prop-2-en-1-one (5e) and (E)-4-(3-(2-(3,3-dimethylbutoxy)-6- hydroxyphenyl)-3-oxoprop-1-enyl)benzenesulfonamide (5p) showed good NF-κB inhibition as well as potent anti-proliferative activity. SAR studies showed that all the compounds with potent or moderate NF-κB inhibition displayed good anti-proliferative activity. All the analogs (5b-r) maintained a good correlation between their NF-κB inhibition and anti-proliferative activity though the extent is not directly proportional to each other.

A SAR study on a series of synthetic lipophilic chalcones as Inhibitor of transcription factor NF-κB

To define the structural features responsible for the activity of 2,4-dihydroxy-6-isopentyloxychalcone, a newly established inhibitor of LPS induced NF-κB activation (IC50 = 10 μM), a series of its analogues was prepared and studied for their i

Structural requirement of chalcones for the inhibitory activity of interleukin-5

Novel chalcones were found as potent inhibitors of interleukin (IL)-5. 1-(2-Benzyloxy-6-hydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one (2b, 78.8% inhibition at 50 μM, IC50 = 25.3 μM) was initially identified as a potent inhibitor of IL-5. Th

Synthesis of (+/-)-Fistacacidin

Synthesis of fistacacidin and (+/-)-2,3-trans-5,4'-dimethoxyflavan-3-ol (XVII) are reported.Synthesis of XII, starting from monobenzyl ether of 2,6-dihydroxyacetophenone (I) involves the reacti