868-10-0

Basic information

• Product Name: Hexanedioic acid, 2-(hydroxyimino)-3-oxo-, diethyl ester
• Synonyms: 2-[(Z)-Hydroxyimino]-3-oxo-hexanedioic acid diethyl ester
• CAS NO: 868-10-0
• Molecular Formula: C10H15NO6
• Molecular Weight: 245.232
• Mol File: 868-10-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Hexanedioic acid, 2-(hydroxyimino)-3-oxo-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Hexanedioic acid, 2-(hydroxyimino)-3-oxo-, diethyl ester(868-10-0)
• EPA Substance Registry System: Hexanedioic acid, 2-(hydroxyimino)-3-oxo-, diethyl ester(868-10-0)

Safety Data

• Hazardous Substances Data: 868-10-0(Hazardous Substances Data)

Upstream product

• 7149-59-9 diethyl 3-oxoadipate 
• 2033-24-1 cycl-isopropylidene malonate 
• 81803-80-7 4-(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-4-oxo-butyric acid methyl ester 

Downstream Products

• 5451-09-2 5-aminolevulinic acid hydrochloride 
• 80505-10-8 benzyl 5-formyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl<5-13C>pyrrole-2-carboxylate 
• 80504-97-8 benzyl 3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-5-methyl<5-13C>pyrrole-2-carboxylate 

Relevant articles and documents

Preparation methods for 5-aminolevulinic acid hydrochloride and 5-aminolevulinic acid hydrochloride intermediate

The invention discloses preparation methods for a 5-aminolevulinic acid hydrochloride and a 5-aminolevulinic acid hydrochloride intermediate. The preparation method for the 5-aminolevulinic acid hydrochloride intermediate comprises: (1) carrying out a reaction on a compound 2 and isopropylidene malonate in an organic solvent under the actions of an organic alkali and a condensing agent to obtain acompound 3; and (2) carrying out a reaction on the compound 3 in a C1-C4 alcohol solvent to obtain a compound 4, wherein R1 and R' are respectively and independently C1-C4 alkyl. The present invention further provides a method for preparing a 5-aminolevulinic acid hydrochloride by using the 5-aminolevulinic acid hydrochloride intermediate. According to the present invention, the intermediate product is basically solid and is easily crystallized and purified; and the method has characteristics of high yield, low production cost and easy operation, and is suitable for industrial production. Thecompounds 1, 2, 3 and 4 are defined in the specification.

Biosynthesis of Porphyrins and Related Macrocycles. Part 16. Proof that the Single Intramolecular Rearrangement leading to Natural Porphyrins (Type-III) occurs at the Tetrapyrrole Level

The unrearranged aminomethylbilane (2) is synthesised by a rational route and is proved to be converted by the enzymes deaminase and cosynthetase, working co-operatively, into uro'gen-III (3).The single rearrangement step established earlier is thus proved to take place at the tetrapyrrole level.Synthesis of singly 13C-labelled bilane (2) followed by its enzymic conversion into uro'gen-III serves to register each of the pyrrole rings of the product relative to the initial bilane.Finally, methods for synthesis of the bilane are developed in two different doubly 13C-labelled forms to allow the following key points to be established largely by 13C n.m.r. spectroscopy: (a) as the bilane system is converted into uro'gen-III, intramolecular rearrangement of the terminal ring D occurs, and (b) the linear tetrapyrrole is converted intact into uro'gen-III.Syntheses of -, and -uroporphyrin octamethyl ester are described together with improved h.p.l.c. conditions for the separation of isomeric coproporphyrin tetramethyl esters.